2'-氨基-4',5'-二甲氧基苯乙酮合成路线 （共 16 条）
反应条件
iron; acetic acid in water; ethyl acetate 6 h; Heating;
参考文献
Butin, Alexander V.; Smirnov, Sergey K.; Stroganova, Tatyana A.; Bender, Wolfgang; Krapivin, Gennady D.
Tetrahedron, 2007 , vol. 63, # 2 p. 474 - 491
反应条件
1: 57 percent / HNO3; AcOH / 0.5 h / 0 - 20 °C 2: 72 percent / Fe; AcOH / H2O; ethyl acetate / 6 h / Heating View Scheme
参考文献
Simpson
Journal of the Chemical Society, 1946 , p. 96
反应条件
1: AlCl3 / benzene / 2.5 h / 55 - 60 °C 2: 57 percent / HNO3; AcOH / 0.5 h / 0 - 20 °C 3: 72 percent / Fe; AcOH / H2O; ethyl acetate / 6 h / Heating View Scheme
参考文献
Butin, Alexander V.; Smirnov, Sergey K.; Stroganova, Tatyana A.; Bender, Wolfgang; Krapivin, Gennady D.
Tetrahedron, 2007 , vol. 63, # 2 p. 474 - 491
参考文献
Mannich; Berger
Archiv der Pharmazie (Weinheim, Germany), 1939 , vol. 277, p. 117,126
参考文献
Simpson
Journal of the Chemical Society, 1946 , p. 96
参考文献
Simpson
Journal of the Chemical Society, 1946 , p. 96
反应条件
1.1: NaOMe / 1,2-dimethoxy-ethane / 1.17 h / 20 °C 1.2: 95 percent / 1,2-dimethoxy-ethane / 2 h / 20 °C 2.1: POCl3 / Heating View Scheme
参考文献
Kubo, Kazuo; Shimizu, Toshiyuki; Ohyama, Shin-Ichi; Murooka, Hideko; Iwai, Akemi; Nakamura, Kazuhide; Hasegawa, Kazumasa; Kobayashi, Yoshiko; Takahashi, Noriko; Takahashi, Kazumi; Kato, Shinichiro; Izawa, Toshio; Isoe, Toshiyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1359 - 1366
反应条件
1.1: NaOMe / 1,2-dimethoxy-ethane / 1.17 h / 20 °C 1.2: 95 percent / 1,2-dimethoxy-ethane / 2 h / 20 °C 2.1: POCl3 / Heating 3.1: Heating 4.1: H2; Et3N / Pd(OH)2/C / dimethylformamide / 20 °C View Scheme
参考文献
Kubo, Kazuo; Shimizu, Toshiyuki; Ohyama, Shin-Ichi; Murooka, Hideko; Iwai, Akemi; Nakamura, Kazuhide; Hasegawa, Kazumasa; Kobayashi, Yoshiko; Takahashi, Noriko; Takahashi, Kazumi; Kato, Shinichiro; Izawa, Toshio; Isoe, Toshiyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1359 - 1366
反应条件
acetic acid Friedlaender reaction; 2 h; Heating;
参考文献
Malecki, Natacha; Carato, Pascal; Rigo, Benoit; Goossens, Jean-Francois; Houssin, Raymond; Bailly, Christian; Henichart, Jean-Pierre
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 3 p. 641 - 647
反应条件
1: HCl / diethyl ether; CH2Cl2 / 20 °C 2: 99 percent / 1 h / 140 °C 3: conc. NH4OH / methanol / 20 °C / pH 10 View Scheme
参考文献
Makhey, Darshan; Yu, Chiang; Liu, Angela; Liu, Leroy F.; Lavoie, Edmond J.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1171 - 1182
