3-(3-溴丙基)吡啶氢溴酸盐合成路线 （共 6 条）
反应条件
1: 1.) Na / 1.) EtOH, 2.) EtOH, reflux, 10 h 2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 60 deg C, 10 h 3: NaN3, NaI, 18-crown-6 / dimethylformamide / 18 h / 60 °C View Scheme
参考文献
Bhagwat; Gude; Boswell; Contardo; Cohen; Dotson; Mathis; Lee; Furness; Zoganas
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4373 - 4383
反应条件
hydrogen bromide
5 h; Heating;
参考文献
Made, A. W. van der; Nolte, R. J. M.; Drenth, W.
Recueil des Travaux Chimiques des Pays-Bas, 1990 , vol. 109, # 11 p. 537 - 551
反应条件
1: 1.) Na, NH3 (liq.) / 1.) -78 deg C, 1 h, 2.) RT, overnight
2: 48percent HBr / Heating
View Scheme
参考文献
Abou-Gharbia; Patel; Moyer; Muth
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1100 - 1105
反应条件
in N-methyl-acetamide
参考文献
The Du Pont Merck Pharmaceutical Company
Patent: US5356906 A1, 1994 ;
反应条件
1: 65 percent
2: 93 percent
3: 86 percent / H2O; methanol
View Scheme
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
反应条件
1: 65 percent
2: 93 percent
3: 86 percent / H2O; methanol
4: 92 percent
View Scheme
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
