3-(吡啶-3-基)-1-丙胺合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 1 h;
参考文献
HUMAN BIOMOLECULAR RESEARCH INSTITUTE
Patent: WO2005/66162 A1, 2005 ;
Location in patent: Page/Page column 62 ;
WO 2005/066162 A1
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
反应条件
1: 84 percent / aq. sodium carbonate; CuI / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 1 h / 90 °C
2: 97 percent / H2 / Pd/C / methanol / 24 h
3: 68 percent / TFA / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Yano, Jason K.; Denton, Travis T.; Cerny, Matthew A.; Zhang, Xiaodong; Johnson, Eric F.; Cashman, John R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 6987 - 7001
反应条件
1: 97 percent / H2 / Pd/C / methanol / 24 h
2: 68 percent / TFA / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Yano, Jason K.; Denton, Travis T.; Cerny, Matthew A.; Zhang, Xiaodong; Johnson, Eric F.; Cashman, John R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 6987 - 7001
反应条件
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C
2: hydrazine hydrate / ethanol / 20 °C
View Scheme
参考文献
Geyer, Roland; Igel, Patrick; Kaske, Melanie; Elz, Sigurd; Buschauer, Armin
MedChemComm, 2014 , vol. 5, # 1 p. 72 - 81
反应条件
1: 85 percent
2: 86 percent
View Scheme
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
