4-氯甲基-7-甲氧基色烯-2-酮合成路线 （共 14 条）
反应条件
1: potassium fluoride / N,N-dimethyl-formamide / 48 h / 20 °C
2: water / methanol / 0.53 h / pH 7.2 / Photolysis; aq. HEPES buffer
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参考文献
McCarron, Stephen T.; Feliciano, Mariel; Johnson, Jeffreys N.; Chambers, James J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 8 p. 2395 - 2398
反应条件
1: 82 percent / acetonitrile / 18 h / Heating
2: 91 percent / 15percent Na2CO3 / 2 h / Ambient temperature
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参考文献
Findlay; Mebe; Stern; Givner
Canadian Journal of Chemistry, 1980 , vol. 58, # 14 p. 1427 - 1434
反应条件
potassium iodide in dichloromethane
14 h; Heating;
参考文献
Kele, Peter; Nagy, Krisztina; Kotschy, Andras
Angewandte Chemie - International Edition, 2006 , vol. 45, # 16 p. 2565 - 2567
反应条件
1: sodium ethanolate / ethanol / 0.33 h / 20 °C
2: sulfuric acid; water / 0.5 h / 20 °C
View Scheme
参考文献
Zwergel, Clemens; Valente, Sergio; Salvato, Angela; Xu, Zhanjie; Talhi, Oualid; Mai, Antonello; Silva, Artur; Altucci, Lucia; Kirsch, Gilbert
MedChemComm, 2013 , vol. 4, # 12 p. 1571 - 1579
