1-甲氧基-2-苯基乙炔-苯合成路线 （共 52 条）
反应条件
2,6-di-tert-butyl-4-methylpyridine; gold(I) chloride; palladium dichloride; SIDip*HCl in acetonitrile
T=20°C; Sonogashira coupling;
参考文献
Panda, Biswajit; Sarkar, Tarun K.
Chemical Communications, 2010 , vol. 46, # 18 p. 3131 - 3133
反应条件
2,6-dimethylpyridine; oxygen; copper(I) bromide in methanol
T=45°C; Sonogashira coupling; P=760.051 Torr; 16 h;
参考文献
Yasukawa, Tomohiro; Miyamura, Hiroyuki; Kobayashi, Sh
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 18 p. 6208 - 6210
反应条件
diisopropyl-carbodiimide in dichloromethane
T=25°C; 24 h; Inert atmosphere;
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
参考文献
McNeilab, Inc.
Patent: US4652584 A1, 1987 ;
反应条件
copper(l) chloride; palladium dichloride; tris(p-fluoro phenyl)phosphine in N,N-dimethyl-formamide
T=100°C; sila-Sonogashira-Hagihara cross-coupling; 12 h; Inert atmosphere;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
1: 2-methoxy-phenylamine With tert.-butylnitrite; boron trifluoride diethyl etherate in tetrahydrofuran
T=0°C;
2: phenylacetylene With 2,6-di-tert-butyl-4-methylpyridine; gold(I) chloride; palladium dichloride; SIDip*HCl in tetrahydrofuran; acetonitrile
T=20°C; Sonogashira coupling;
参考文献
Panda, Biswajit; Sarkar, Tarun K.
Chemical Communications, 2010 , vol. 46, # 18 p. 3131 - 3133
反应条件
pyrrolidine
T=100°C; Sonogashira coupling; 0.5 h; Microwave irradiation;
参考文献
Carpita, Adriano; Ribecai, Arianna
Tetrahedron Letters, 2009 , vol. 50, # 2 p. 204 - 207
反应条件
C32H28BrFeIN3Pd; potassium acetate; silver(l) oxide in 1,2-dichloro-ethane
T=80°C; 24 h;
参考文献
Li, Hong-Mei; Xu, Chen; Duan, Lu-Meng; Lou, Xin-Hua; Wang, Zhi-Qiang; Li, Zhen; Fan, Yao-Ting
Transition Metal Chemistry, 2013 , vol. 38, # 3 p. 313 - 318
反应条件
tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine; tetrabutyl ammonium fluoride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=90°C; 12 h;
参考文献
Moon, Jeongju; Jang, Mihee; Lee, Sunwoo
Journal of Organic Chemistry, 2009 , vol. 74, # 3 p. 1403 - 1406
反应条件
1: methoxybenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Inert atmosphere;
2: 1-(4'-methylphenylsulfonyl)-2-phenylethyne in tetrahydrofuran; hexane
T=-78°C; 0.0833333 h; Inert atmosphere; regioselective reaction;
参考文献
Garcia Ruano, Jose Luis; Aleman, Jose; Marzo, Leyre; Alvarado, Cuauhtemoc; Tortosa, Mariola; Diaz-Tendero, Sergio; Fraile, Alberto
Chemistry - A European Journal, 2012 , vol. 18, # 27 p. 8414 - 8422
