反应条件
1: 1,2-dichloro-ethane / 4 h / Heating 2: 3.64 g / AcCl / 1,2-dichloro-ethane / 1 h / Heating 3: 76 percent / BF3*Et2O; NaBH4 / various solvent(s) / 4.25 h / 0 - 20 °C 4: 96 percent / aq. LiOH / tetrahydrofuran; methanol / 18 h / 20 °C View Scheme
参考文献
Wendt, Michael D.; Shen, Wang; Kunzer, Aaron; McClellan, William J.; Bruncko, Milan; Oost, Thorsten K.; Ding, Hong; Joseph, Mary K.; Zhang, Haichao; Nimmer, Paul M.; Ng, Shi-Chung; Shoemaker, Alexander R.; Petros, Andrew M.; Oleksijew, Anatol; Marsh, Kennan; Bauch, Joy; Oltersdorf, Tilman; Belli, Barbara A.; Martineau, Darlene; Fesik, Stephen W.; Rosenberg, Saul H.; Elmore, Steven W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1165 - 1181