1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
1: 82 percent / aq. KOH, Br2 / diethyl ether / 2 h / 2 - 4 °C
2: 67 percent / Jones reagent / acetone
View Scheme
参考文献
Glotova; Komarova; Nakhmanovich; Lopyrev
Russian Chemical Bulletin, 2000 , vol. 49, # 11 p. 1917 - 1918
反应条件
1: 1.) Li, FeCl3, NH3 / 1.) THF, r.t., 1.5 h, 2.) THF, 1 h
2: 93 percent / H2, quinoline / Pd-BaSO4 / hexane / 2 h / 0 °C
3: 1.) n-BuLi / 1.) <Rh(dppe)COD>ClO4 / 1.) THF, hexane, reflux, 6 h, 2.) THF, hexane
View Scheme
参考文献
Gazzard, Lewis J.; Motherwell, William B.; Sandham, David A.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 8 p. 979 - 993
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 °C
1.2: 74 percent / tetrahydrofuran / -78 - 20 °C
2.1: 20 percent Spectr. / [Ru(PPh3)3(CO)H2]; Xantphos; propanoic acid / toluene / 24 h / 110 °C
View Scheme
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5111 - 5114
反应条件
1: Br2; NaOH / ethanol; diethyl ether / 3 h / 20 °C
2: 76 percent / MnO2 / 1 h / 20 °C
3: 83 percent / BF3*Et2O / acetic acid / 1 h / 40 °C
4: 95 percent / aq. ethanol / 30 h
View Scheme
参考文献
Glotova; Komarova; Nakhmanovich; Lopyrev
Russian Chemical Bulletin, 2000 , vol. 49, # 11 p. 1917 - 1918
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in dichloromethane
T=45°C; Hydrosilylation; 3 h;
参考文献
Na, Youngim; Chang, Sukbok
Organic Letters, 2000 , vol. 2, # 13 p. 1887 - 1889
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran
T=150°C; 0.5 h; microwave irradiation;
参考文献
Schramm, Oana G.; Oeser, Thomas; Kaiser, Marcel; Brun, Reto; Mueller, Thomas J. J.
Synlett, 2008 , # 3 p. 359 - 362
