alpha-(4-溴苯基)-alpha-[2-(二甲基氨基)乙基]-3-吡啶甲醇合成路线 （共 3 条）
反应条件
n-butyllithium in diethyl ether; hexane 1.) -60 deg C, 1 h, 2.) -40 to -30 deg C, 50 min, 3.) to room temperature, 2.5 h;
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
sulfuric acid; acetic anhydride 0.5 h; Heating; Yield given;
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: conc. H2SO4, Ac2O / 0.5 h / Heating
2: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
3: 41 percent / dimethylformamide / 3 h / 80 °C
4: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
