(S)-(+)-3-甲基-1-戊醇合成路线 （共 30 条）
参考文献
Jensen,R.B. et al.
Acta Chemica Scandinavica (1947-1973), 1972 , vol. 26, p. 667 - 684
反应条件
(i) Li, Et2O, (ii) /BRN= 1209228/, (iii) H2O; Multistep reaction;
参考文献
Lardicci,L.; Pino,P.
Gazzetta Chimica Italiana, 1961 , vol. 91, p. 441 - 457
参考文献
Levene; Marker
Journal of Biological Chemistry, 1931 , vol. 91, p. 697
参考文献
Levene; Marker
Journal of Biological Chemistry, 1931 , vol. 91, p. 95
Journal of Biological Chemistry, 1936 , vol. 115, p. 272
反应条件
sodium dichromate; sulfuric acid in diethyl ether Ambient temperature;
参考文献
Yissum Research Development Company of the Hebrew University of Jerusalem
Patent: US6417399 B1, 2002 ;
反应条件
bromine; triphenylphosphine in tetrachloromethane
参考文献
Chattopadhyay; Chadha; Mamdapur
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 2 p. 247 - 249
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 1 h;
参考文献
Thurnhofer, Saskia; Vetter, Walter
Tetrahedron, 2007 , vol. 63, # 5 p. 1140 - 1145
反应条件
1: PBr3, Py
2: (i) Mg, (ii) /BRN= 1900390/, Et2O
View Scheme
参考文献
Salvadori,P. et al.
Gazzetta Chimica Italiana, 1968 , vol. 98, p. 1400 - 1416
反应条件
1: 58 percent / aq. Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
2: oxalyl chloride, DMF / CH2Cl2 / 1 h / 0 °C
3: 1.) BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) from -78 deg C to 0 deg C, b) 0 deg C, 2 h
View Scheme
参考文献
Roeder, Michael; Spiegelstein, Ofer; Schurig, Volker; Bialer, Meir; Yagen, Boris
Tetrahedron Asymmetry, 1999 , vol. 10, # 5 p. 841 - 853
反应条件
1: 58 percent / aq. Na2Cr2O7, H2SO4 / diethyl ether / Ambient temperature
2: oxalyl chloride, DMF / CH2Cl2 / 1 h / 0 °C
3: 1.) BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) from -78 deg C to 0 deg C, b) 0 deg C, 2 h
View Scheme
参考文献
Roeder, Michael; Spiegelstein, Ofer; Schurig, Volker; Bialer, Meir; Yagen, Boris
Tetrahedron Asymmetry, 1999 , vol. 10, # 5 p. 841 - 853
