2-硝基-5-(1-哌啶)-苯甲酰胺合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; P=2068.59 Torr; 3 h;
参考文献
Lopez, Simon E.; Rosales, Monica E.; Canelon, Carlos E.; Valverde, Edgar A.; Narvaez, Rosa C.; Charris, Jaime E.; Giannini, Fernando A.; Enriz, Ricardo D.; Carrasco, Mirta; Zacchino, Susana
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 473 - 480
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=70°C; 12 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/37814 A1, 2004 ;
Location in patent: Page 177 ;
WO 2004/037814 A1
参考文献
Lopez, Simon E.; Rosales, Monica E.; Canelon, Carlos E.; Valverde, Edgar A.; Narvaez, Rosa C.; Charris, Jaime E.; Giannini, Fernando A.; Enriz, Ricardo D.; Carrasco, Mirta; Zacchino, Susana
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 473 - 480
反应条件
1: SOCl2 / benzene / 4 h / Heating
2: NH3(g) / benzene / 20 °C
3: dimethylformamide / 3 h / 110 °C
View Scheme
参考文献
Hour; Huang; Kuo; Xia; Bastow; Nakanishi; Hamel; Lee
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4479 - 4487
反应条件
1: NH3(g) / benzene / 20 °C
2: dimethylformamide / 3 h / 110 °C
View Scheme
参考文献
Hour; Huang; Kuo; Xia; Bastow; Nakanishi; Hamel; Lee
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4479 - 4487
