hydrazine hydrate NaOH, pH= 10;

1: 45 percent / dimethylformamide / 4 h / 80 °C 2: 92 percent / NH2NH2*H2O / NaOH, pH= 10 View Scheme

sodium hydroxide in methanol

1: H2SO4 2: aq. NaOH / methanol View Scheme

1: isopentylnitrite, NaOAc 2: H2SO4 3: aq. NaOH / methanol View Scheme

1: α-hydroxy-isovaleric acid t-butyl ester With [Cu(S,S)-t-Bu-box]OTf2 in dichloromethane T=0°C; 0.166667 h; Inert atmosphere; 2: 1-isocyanatopropane in dichloromethane T=0°C; 1 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

(i) TsOH, CH2Cl2, (ii) H2, PdO, MeOH; Multistep reaction;