2-羟基-1,2,2-三苯乙酮合成路线 （共 78 条）
反应条件
in diethyl ether
Grignard reaction; 5 h;
参考文献
Ashraf, M. Arfan; Russell, Alexander G.; Wharton, Christopher W.; Snaith, John S.
Tetrahedron, 2007 , vol. 63, # 3 p. 586 - 593
反应条件
lithium perchlorate; potassium carbonate in acetonitrile
24 h; electrooxidation: 1.00 V, 2.05 F/mol;
参考文献
Cariou, Michel
Bulletin de la Societe Chimique de France, 1988 , # 6 p. 1015 - 1021
反应条件
1: bromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: oxalic acid diethyl ester in tetrahydrofuran; hexane
T=-78°C; 0.25 h;
3: With water; acetic acid in tetrahydrofuran; hexane
T=-78°C; 0.0833333 h; Temperature;
参考文献
Nagaki, Aiichiro; Ichinari, Daisuke; Yoshida, Jun-Ichi
Chemical Communications, 2013 , vol. 49, # 31 p. 3242 - 3244
反应条件
Yield given. Multistep reaction;
参考文献
Koenigkramer, Rusty E.; Zimmer, Hans
Tetrahedron Letters, 1980 , vol. 21, p. 1017 - 1020
反应条件
1: 55 percent / K2CO3, LiClO4 / acetonitrile / 18 h / electrooxidation: 1.40 V, 1.90 F/mol
2: 50 percent / NaH / dimethylsulfoxide
3: 20 percent / K2CO3, LiClO4 / acetonitrile / 24 h / electrooxidation: 1.00 V, 2.05 F/mol
View Scheme
参考文献
Cariou, Michel
Bulletin de la Societe Chimique de France, 1988 , # 6 p. 1015 - 1021
反应条件
(i) Et2O, (ii) H2O; Multistep reaction;
参考文献
Trzupek,L.S. et al.
Journal of the American Chemical Society, 1973 , vol. 95, p. 8118 - 8133
反应条件
samarium diiodide in tetrahydrofuran
5 h; Heating; Product distribution; Further Variations:Reaction partnersTemperatures;
参考文献
Liu, Yunkui; Zhang, Yongmin
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5745 - 5748
反应条件
1: 1. LDA / 1. THF, cyclohexane, -78 deg C, 30 min, 2a. 30 min, 2b. RT, overnight
2: 82 percent / aq. sodium acetate / 2 h / Ambient temperature
View Scheme
参考文献
Olah, George A.; Wu, An-hsiang
Journal of Organic Chemistry, 1991 , vol. 56, # 7 p. 2531 - 2534
反应条件
1: 1. LDA / 1. THF, cyclohexane, -78 deg C, 30 min, 2a. 30 min, 2b. RT, overnight
2: 82 percent / aq. sodium acetate / 2 h / Ambient temperature
View Scheme
参考文献
Olah, George A.; Wu, An-hsiang
Journal of Organic Chemistry, 1991 , vol. 56, # 7 p. 2531 - 2534
反应条件
1: 94 percent / 4 h / Heating
2: 1.) LDA, 2.) HCl/H2O / 1)THF, -60 deg C, 20 min; 2)reflux
View Scheme
参考文献
Koenigkramer, Rusty E.; Zimmer, Hans
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 3994 - 3998
