4-(苯基乙炔基)苯甲酸合成路线 （共 36 条）
反应条件
copper(l) iodide; [Pt(PPh3)4] in N,N-dimethyl-formamide
T=120°C; 12 h;
参考文献
Oh, Chang Ho; Reddy, V. Raghava
Synlett, 2004 , # 12 p. 2091 - 2094
反应条件
{(Pd{Fe(.eta.5-C5H5)(.eta.5-C5H3C(CH3)=NC6H4CH3-4)}(.mu.-Cl))2}; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in acetonitrile
T=110°C; 16 h; Inert atmosphere;
参考文献
Hu, Hao; Yang, Fan; Wu, Yangjie
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10506 - 10511
反应条件
bis-triphenylphosphine-palladium(II) chloride; triethylamine in water
T=25°C; Sonogashira Cross-Coupling; P=760.051 Torr; 24 h; Green chemistry;
参考文献
Zhao, Hong; Cheng, Mingzhu; Zhang, Jiatao; Cai, Mingzhong
Green Chemistry, 2014 , vol. 16, # 5 p. 2515 - 2522
反应条件
bis-triphenylphosphine-palladium(II) chloride in ethylene glycol dimethyl ether
12 h; Heating;
参考文献
Gelman, Dmitri; Tsvelikhovsky, Dmitry; Molander, Gary A.; Blum, Jochanan
Journal of Organic Chemistry, 2002 , vol. 67, # 18 p. 6287 - 6290
反应条件
tetrabutyl-ammonium chloride; sodium acetate; palladium diacetate in N,N-dimethyl-formamide
T=100°C; Sonogashira coupling; 0.25 h; microwave irradiation;
参考文献
Sorensen, Ulrik S.; Pombo-Villar, Esteban
Tetrahedron, 2005 , vol. 61, # 10 p. 2697 - 2703
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; diethylamine in acetonitrile
T=20°C; Sonogashira coupling; 1 h; Inert atmosphere;
参考文献
Fabrizi, Giancarlo; Goggiamani, Antonella; Sferrazza, Alessio; Cacchi, Sandro
Angewandte Chemie - International Edition, 2010 , vol. 49, # 24 p. 4067 - 4070
反应条件
1: p-aminobenzoic acid methyl ester With tert.-butylnitrite; boron trifluoride diethyl etherate in tetrahydrofuran
T=-15 - 20°C; Inert atmosphere;
2: phenylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; diethylamine in acetonitrile
T=20°C; Sonogashira coupling; 1.5 h;
参考文献
Fabrizi, Giancarlo; Goggiamani, Antonella; Sferrazza, Alessio; Cacchi, Sandro
Angewandte Chemie - International Edition, 2010 , vol. 49, # 24 p. 4067 - 4070
反应条件
MCM-41-supported mercapto palladium(0) complex in water; N,N-dimethyl-formamide
T=60°C; Stille coupling; 12 h;
参考文献
Zhao, Hong; Zheng, Guomin; Hao, Wenyan; Cai, Mingzhong
Applied Organometallic Chemistry, 2010 , vol. 24, # 2 p. 92 - 98
反应条件
[Pd((.eta.5-C5H5)Fe[(.eta.5-C5H3)C(Me)=N(C6H4-4-Me)])(.mu.-Cl)]2; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in anhydrous xylene; water
T=120°C; 3 h;
参考文献
Li, Xi'Ang; Yang, Fan; Wu, Yangjie
Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4543 - 4550
反应条件
1: sodium 2'-[(cyclohexyl)2P]-2,6-(iPr)2-biphenyl-4-sulfonate; PdCl2(CH3CN)2; Cs2CO3 / acetonitrile; H2O / 12 h / 100 °C
2: 101 mg / diethyl ether; methanol / 0.08 h
View Scheme
参考文献
Anderson, Kevin W.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 38 p. 6173 - 6177
