N-(3-噻吩基)乙酰胺合成路线 (共 13 条)
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: US2009/247579 A1, 2009 ;
Location in patent: Page/Page column 44 ;
反应条件
phosphorus pentachloride in diethyl ether 1.) 0 deg C, 2 h, 2.) ambient temperature, 8 h;
参考文献
Meth-Cohn, Otto; Narine, Bramha
Synthesis, 1980 , # 2 p. 133 - 135
反应条件
potassium phosphate; copper(l) iodide; 1,2-diamino-cyclohexane in 1,4-dioxane Inert atmosphereReflux;
参考文献
Heth, Christopher L.; Tallman, Dennis E.; Rasmussen, Seth C.
Journal of Physical Chemistry B, 2010 , vol. 114, # 16 p. 5275 - 5282
反应条件
alkaline aqueous sodium hypobromite solution Behandeln der Reaktionsloesung mit Acetanhydrid;
参考文献
Campaigne; Monroe
Journal of the American Chemical Society, 1954 , vol. 76, p. 2447,2449
反应条件
pyridine hydrochloride reflux, 22h; Yield given. Multistep reaction;
参考文献
Coutts, Ian G. C.; Edwards, Mark; Richards, David J.
Synthesis, 1981 , # 6 p. 487 - 489
反应条件
1: thiophene-3-carboxamide With sodium hydroxide; bromine 2: With water 3: acetic anhydride
参考文献
Raju, Sirisilla; Kumar, P. Rajender; Mukkanti; Annamalai, Pazhanimuthu; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6185 - 6189
反应条件
hydrogenchloride; tin Behandeln einer mit Aether ueberschichteten wss. Loesung mit wss. Natronlauge und mit Acetanhydrid;
参考文献
Steinkopf; Hoepner
Justus Liebigs Annalen der Chemie, 1933 , vol. 501, p. 174,182
反应条件
hydrogenchloride; tin Behandeln einer mit Aether ueberschichteten wss. Loesung mit wss. Natronlauge und mit Acetanhydrid;
参考文献
Motoyama et al.
Nippon Kagaku Zasshi, 1957 , vol. 78, p. 779,783
Chem.Abstr., 1960 , p. 22559
反应条件
in diphenylether 0.333333 h; Heating;
参考文献
Huddleston, Patrick R.; Barker, John M.; Adamczewska, Yolante Z.; Wood, Michael L.; Holmes, David
Journal of Chemical Research, Miniprint, 1993 , # 2 p. 548 - 575
反应条件
Yield given. Multistep reaction;
参考文献
Stoyanovich, F. M.; Marakatkina, M. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1346
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1695 - 1697