反应条件
1: 85 percent / dimethylformamide / 4 h / Heating 2: 94 percent / conc. HCl, H2 / 10 percent Pd/C / ethanol; H2O; methanol / 25 h / 3102.89 Torr 3: 11.0 g / N-methylmorpholine, HOBT*H2O, EDC*HCl / dimethylformamide / 1.) from 0 deg C to RT, 2.) RT, 4 h View Scheme
参考文献
Sanderson, Philip E. J.; Lyle, Terry A.; Cutrona, Kellie J.; Dyer, Dona L.; Dorsey, Bruce D.; McDonough, Colleen M.; Naylor-Olsen, Adel M.; Chen, I.-Wu; Chen, Zhongguo; Cook, Jacquelynn J.; Cooper, Carolyn M.; Gardell, Stephen J.; Hare, Timothy R.; Krueger, Julie A.; Lewis, S. Dale; Lin, Jiunn H.; Lucas Jr., Bobby J.; Lyle, Elizabeth A.; Lynch Jr., Joseph J.; Stranieri, Maria T.; Vastag, Kari; Yan, Youwei; Shafer, Jules A.; Vacca, Joseph P.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4466 - 4474