1: 2 h / 20 °C 2: trifluoroacetic acid / 6 h / 20 °C 3: (CO2H)2 / H2O; diethyl ether / 14 h View Scheme
参考文献
Adlington, Robert M.; Baldwin, Jack E.; Bottaro, Jeffrey C.; Perry, Matthew W. D.
Journal of the Chemical Society, Chemical Communications, 1983 , # 18 p. 1040 - 1041
Baldwin, Jack E.; Adlington, Robert M.; Bottaro, Jeffrey C.; Kolhe, Jayant N.; Perry, Matthew W. D.; Jain, Ashok U.
Tetrahedron, 1986 , vol. 42, # 15 p. 4223 - 4234
1: 2 h / 20 °C 2: trifluoroacetic acid / 6 h / 20 °C 3: (CO2H)2 / H2O; diethyl ether / 14 h View Scheme
参考文献
Adlington, Robert M.; Baldwin, Jack E.; Bottaro, Jeffrey C.; Perry, Matthew W. D.
Journal of the Chemical Society, Chemical Communications, 1983 , # 18 p. 1040 - 1041
Baldwin, Jack E.; Adlington, Robert M.; Bottaro, Jeffrey C.; Kolhe, Jayant N.; Perry, Matthew W. D.; Jain, Ashok U.
Tetrahedron, 1986 , vol. 42, # 15 p. 4223 - 4234
n-butyllithium in hexane 1-iodoheptane (1 equiv.) and TMTH (1 equiv.) in hexane cooled to 0°C under Ar, n-BuLi (1 equiv., 2.40 M in hexane) added, stirred for 15 min, quenched with water; analyzed by GC;
in hexane; cyclohexane to soln. of 1-iodoheptane (1.0 mmol) and TMTH (1.0 mmol) in hexane at 0°C added LDA (1.0 mmol, 1.6 M soln. in cyclohexane) under Ar, react. time 10 min; analyzed by GLPC;
