4-氯-1-(2-噻吩基)丁酮合成路线 （共 12 条）
反应条件
1: γ-chlorobutyryl chloride With 1-methyl-pyrrolidin-2-one in toluene T=0°C; 0.5 h; 2: thien-2-ylmagnesium bromide in tetrahydrofuran; toluene T=-10 - -5°C; 4.25 h; chemoselective reaction;
参考文献
Gowda, Maravanhalli Sidde; Pande, Sushanth Sudhir; Ramakrishna, Ramesha Andagar; Prabhu, Kandikere Ramaiah
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 15 p. 5365 - 5368
反应条件
iron silicate T=25°C; Friedel-Crafts acylation;
参考文献
Borate, Hanumant B.; Gaikwad, Abaji G.; Maujan, Suleman R.; Sawargave, Sangmeshwer P.; Kalal, Kamalakar M.
Tetrahedron Letters, 2007 , vol. 48, # 28 p. 4869 - 4872
反应条件
iron silicate T=25°C;
参考文献
Borate, Hanumant B.; Gaikwad, Abaji G.; Maujan, Suleman R.; Sawargave, Sangmeshwer P.; Kalal, Kamalakar M.
Tetrahedron Letters, 2007 , vol. 48, # 28 p. 4869 - 4872
反应条件
aluminium trichloride; nitromethane in carbon disulfide 3 h; Ambient temperature;
参考文献
El-Khagawa, Ahmed M.; El-Zohry, Maher F.; Ismail, Mohamed T.
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 33, p. 25 - 32
反应条件
in tetrahydrofuran T=0°C;
参考文献
Pablo, Oscar; Guijarro, David; Yus, Miguel
Journal of Organic Chemistry, 2013 , vol. 78, # 18 p. 9181 - 9189
反应条件
iron(III) chloride in carbon disulfide 3 h; Ambient temperature; Further byproducts given;
参考文献
El-Khagawa, Ahmed M.; El-Zohry, Maher F.; Ismail, Mohamed T.
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 33, p. 25 - 32
反应条件
iron(III) chloride in carbon disulfide 3 h; Ambient temperature; Further byproducts given;
参考文献
El-Khagawa, Ahmed M.; El-Zohry, Maher F.; Ismail, Mohamed T.
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 33, p. 25 - 32
反应条件
iron(III) chloride in carbon disulfide 3 h; Ambient temperatureother catalyst; Product distribution;
参考文献
El-Khagawa, Ahmed M.; El-Zohry, Maher F.; Ismail, Mohamed T.
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 33, p. 25 - 32
参考文献
Hadjipavlou-Litina, D; Rekka, E; Hadjipetrou-Kourounakis, L; Kourounakis, P
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 1 p. 85 - 90
反应条件
n-butyllithium in diethyl ether; hexane 1.) -65 deg C, 3 h, 2.) room temperature;
参考文献
Sonnewald, Ursula
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 8 p. 567 - 568
