2-环己基-2-羟基苯乙酸合成路线 （共 28 条）
反应条件
1: LDA / tetrahydrofuran / -78 - 20 °C 2: KOH / ethanol / 20 °C View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Formentin, Pilar; Pedro, Jose R.; Rosello, Antonio L.; Ruiz, Rafael; Journaux, Yves
Tetrahedron Letters, 1998 , vol. 39, # 20 p. 3327 - 3330
反应条件
sodium hydroxide T=100°C; 3 h;
参考文献
El-Gindy, Alaa
Farmaco, 2005 , vol. 60, # 8 p. 689 - 699
反应条件
1: LDA 2: NaOH View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Formentin, Pilar; Pedro, Jose R.; Rosello, Antonio L.; Ruiz, Rafael; Journaux, Yves
Tetrahedron Letters, 1998 , vol. 39, # 20 p. 3327 - 3330
反应条件
1: LDA 2: NaOH View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Formentin, Pilar; Pedro, Jose R.; Rosello, Antonio L.; Ruiz, Rafael; Journaux, Yves
Tetrahedron Letters, 1998 , vol. 39, # 20 p. 3327 - 3330
反应条件
Tris-HCl buffer; human liver carboxylesterase pI 4.5 T=37°C; Hydrolysis; pH=7.4; Enzyme kinetics;
参考文献
Takai, Satomi; Matsuda, Ayuka; Usami, Yoshiko; Adachi, Tetsuo; Sugiyama, Tadashi; Katagiri, Yoshihiro; Tatematsu, Masae; Hirano, Kazuyuki
Biological and Pharmaceutical Bulletin, 1997 , vol. 20, # 8 p. 869 - 873
反应条件
human liver cytosol T=37°C; pH=7.6; aq. bufferEnzymatic reaction; Kinetics; Reagent/catalyst;
参考文献
Sato, Yuichiro; Miyashita, Aiji; Iwatsubo, Takafumi; Usui, Takashi
Drug Metabolism and Disposition, 2012 , vol. 40, # 5 p. 902 - 906
参考文献
Smith et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4534
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
oxygen; copper diacetate in dimethyl sulfoxide T=120°C; 10 h; Sealed tube;
参考文献
Feng, Qiang; Song, Qiuling
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1867 - 1871
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 231 - 241
