2,2,2-三氟苯乙酮合成路线 （共 295 条）
反应条件
sulfuric acid; dibromoisocyanuric acid 10 deg C to RT;
参考文献
Kogon, Alexander A.; Bochkariov, Dmitry E.; Baskunov, Boris P.; Cheprakov, Andrew V.
Liebigs Annalen der Chemie, 1992 , # 8 p. 879 - 882
反应条件
1: 90 percent 2: 61 percent / hydrolysis 3: 20 g / SOCl2 View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 36, # 8 p. 499 - 504
反应条件
hydrogen in toluene T=20°C; Orito reaction; P=750.075 Torr; optical yield given as percent eeenantioselective reaction;
参考文献
Balazsik, Katalin; Szori, Kornel; Szollosi, Gyoergy; Bartok, Mihaly
Catalysis Communications, 2011 , vol. 12, # 15 p. 1410 - 1414
反应条件
1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: cyclohexanone in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 3: 2,2,2-Trifluoro-1-phenyl-ethanone in tetrahydrofuran; diethyl ether T=20°C; 1 h;
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Bum Tae
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7213 - 7216
反应条件
1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: butyraldehyde in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 3: 2,2,2-Trifluoro-1-phenyl-ethanone in tetrahydrofuran; diethyl ether T=20°C; 1 h;
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Bum Tae
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7213 - 7216
反应条件
1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: 2,2,2-Trifluoro-1-phenyl-ethanone in tetrahydrofuran; diethyl ether T=20°C; 1 h;
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Bum Tae
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7213 - 7216
反应条件
in tetrahydrofuran T=0 - 20°C; Cannizzaro-type reaction; Inert atmosphere;
参考文献
Dalton Transactions, , vol. 39, # 41 p. 9823 - 9829
反应条件
1.1: 52 percent 2.1: 73 percent / NaH / tetrahydrofuran / 20 °C 3.1: O3 / CH2Cl2 / -78 °C 3.2: 54 percent / Me2S / CH2Cl2 / -78 - 20 °C 4.1: NaClO2; KH2PO4; isobutene / 2-methyl-propan-2-ol; H2O / 16 h / 20 °C View Scheme
参考文献
Bravo, Pierfrancesco; Frigerio, Massimo; Resnati, Guiseppe
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4216 - 4218
反应条件
sodium nitrate; sulfuric acid T=0°C; 1 h;
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 89; 90 ;
反应条件
oxygen; iron(III) chloride; nitrogen(IV) oxide; ozone in dichloromethane T=-10 - 0°C; 1 h; Yields of byproduct given;
参考文献
Suzuki; Tatsumi; Maeda
Synthesis, 1995 , # 11 p. 1353 - 1354
