5-甲基环己烷-1,3-二酮合成路线 （共 53 条）
反应条件
1.1: 99 percent / 0.75 h / 80 °C 2.1: 94 percent / SOCl2 3.1: Mg / diethyl ether / 0.5 h / Heating 3.2: CdCl2 / diethyl ether / 0.75 h / Heating 3.3: 66 percent / toluene / 2 h / Heating 4.1: KOtBu / 2-methyl-propan-2-ol 4.2: 53 percent / HCl / tetrahydrofuran; H2O View Scheme
参考文献
Boers, Rutger B.; Gast, Peter; Hoff, Arnold J.; De Groot, Huub J. M.; Lugtenburg, Johan
European Journal of Organic Chemistry, 2002 , # 1 p. 189 - 202
反应条件
1.1: 94 percent / SOCl2 2.1: Mg / diethyl ether / 0.5 h / Heating 2.2: CdCl2 / diethyl ether / 0.75 h / Heating 2.3: 66 percent / toluene / 2 h / Heating 3.1: KOtBu / 2-methyl-propan-2-ol 3.2: 53 percent / HCl / tetrahydrofuran; H2O View Scheme
参考文献
Boers, Rutger B.; Gast, Peter; Hoff, Arnold J.; De Groot, Huub J. M.; Lugtenburg, Johan
European Journal of Organic Chemistry, 2002 , # 1 p. 189 - 202
反应条件
1.1: Mg / diethyl ether / 0.5 h / Heating 1.2: CdCl2 / diethyl ether / 0.75 h / Heating 1.3: 66 percent / toluene / 2 h / Heating 2.1: KOtBu / 2-methyl-propan-2-ol 2.2: 53 percent / HCl / tetrahydrofuran; H2O View Scheme
参考文献
Boers, Rutger B.; Gast, Peter; Hoff, Arnold J.; De Groot, Huub J. M.; Lugtenburg, Johan
European Journal of Organic Chemistry, 2002 , # 1 p. 189 - 202
反应条件
(i) aq. EtOH, KOH, (ii) aq. HCl; Multistep reaction;
参考文献
Stork,G.; Tomasz,M.
Journal of the American Chemical Society, 1964 , vol. 86, p. 471 - 478
反应条件
sodium hydroxide; sulfuric acid 1.) water, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Edafiogho; Hinko; Chang; Moore; Mulzac; Nicholson; Scott
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2798 - 2805
反应条件
sodium hydroxide; sulfuric acid 1.) water, reflux, 1 h; Multistep reaction;
参考文献
Edafiogho; Hinko; Chang; Moore; Mulzac; Nicholson; Scott
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2798 - 2805
反应条件
1: 1.) sodium methanolate / 1.) 0 deg C, 30 min, 2.) a) 0 deg C, 1 h, b) reflux, 2 h 2: 1.) 5 M NaOH, 2.) 5 M H2SO4 / 1.) water, reflux, 1 h View Scheme
参考文献
Edafiogho; Hinko; Chang; Moore; Mulzac; Nicholson; Scott
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2798 - 2805
反应条件
toluene-4-sulfonic acid
参考文献
Wang, Ze-Jun; Sun, Liqin; Jackson, Patrice L.; Scott, Kenneth R.; Heinbockel, Thomas
Journal of Pharmacology and Experimental Therapeutics, 2011 , vol. 336, # 3 p. 916 - 924
反应条件
ethanol; ammonia; sodium Erwaermen des Reaktionsprodukts mit wss. HCl;
参考文献
Birch; Rickards
Australian Journal of Chemistry, 1956 , vol. 9, p. 241
反应条件
sodium ethanolate anschliessendes Erhitzen mit wss. KOH;
参考文献
Kvita; Weichet
Collection of Czechoslovak Chemical Communications, 1957 , vol. 22, p. 1064
