3-(3-甲氧基苯基)吡啶合成路线 （共 28 条）
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran 2: With zinc dibromide in tetrahydrofuran 3: 3-bromo-pyridine With 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride in tetrahydrofuran T=25°C; Negishi cross-coupling; 1 h;
参考文献
Gavryushin, Andrei; Kofink, Christiane; Manolikakes, Georg; Knochel, Paul
Tetrahedron, 2006 , vol. 62, # 32 p. 7521 - 7533
反应条件
palladium diacetate; tris-(o-tolyl)phosphine in toluene T=20°C; 5 h; Inert atmosphere;
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
1: trifluoro(3-methoxyphenyl)silane With tetrabutyl ammonium fluoride; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tert-butyl alcohol T=20°C; Hiyama cross-coupling reaction; 0.0833333 h; Inert atmosphereSealed vial; 2: 3-chloro-pyridine in tert-butyl alcohol T=60°C; Hiyama cross-coupling reaction; Inert atmosphereSealed vial;
参考文献
Molander, Gary A.; Iannazzo, Laura
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9182 - 9187
反应条件
1: 85 percent / Et3N / toluene / 12 h / Heating 2: 85 percent / NiClCpIMes / diethyl ether; tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Macklin, Todd K.; Snieckus, Victor
Organic Letters, 2005 , vol. 7, # 13 p. 2519 - 2522
反应条件
potassium phosphate; Ni(PCy3)2Cl2; PCy3∙HBF4 in o-xylene T=150°C; Suzuki-Miyaura cross-coupling; 5 - 20 h; Inert atmosphere;
参考文献
Quasdorf, Kyle W.; Antoft-Finch, Aurora; Liu, Peng; Silberstein, Amanda L.; Komaromi, Anna; Blackburn, Tom; Ramgren, Stephen D.; Houk; Snieckus, Victor; Garg, Neil K.
Journal of the American Chemical Society, 2011 , vol. 133, # 16 p. 6352 - 6363
反应条件
potassium hydroxide; tetrakis(triphenylphosphine) palladium(0); tetra-(n-butyl)ammonium iodide in tetrahydrofuran 12 h; Heating;
参考文献
Sonesson, Clas; Lindborg, Jonas
Tetrahedron Letters, 1994 , vol. 35, # 48 p. 9063 - 9066
反应条件
1,10-phenanthroline; palladium diacetate; caesium carbonate T=150°C; 48 h; Sealed tubeInert atmosphere; regioselective reaction;
参考文献
Dai, Fenglin; Gui, Qingwen; Liu, Jidan; Yang, Zhiyong; Chen, Xiang; Guo, Ruqing; Tan, Ze
Chemical Communications, 2013 , vol. 49, # 41 p. 4634 - 4636
反应条件
1.1: n-butyllithium / diethyl ether / 2 h / -78 °C 1.2: 3 h / -78 °C 2.1: C37H51ClFeNPPd; copper(l) iodide; cesium fluoride / N,N-dimethyl-formamide / 12 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; LaFe0.95Pd0.05O(3-x); potassium carbonate in water; isopropyl alcohol T=80°C; Suzuki-Miyaura Coupling; 20 h; Inert atmosphere; Catalytic behavior;
参考文献
Misch, Lauren M.; Birkel, Alexander; Figg, C. Adrian; Fors, Brett P.; Hawker, Craig J.; Stucky, Galen D.; Seshadri, Ram
Dalton Transactions, 2014 , vol. 43, # 5 p. 2079 - 2087
反应条件
1.1: sodium hexafluorosilicate / 1 h / 200 °C / Inert atmosphere 2.1: tetrabutyl ammonium fluoride; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tert-butyl alcohol / 0.08 h / 20 °C / Inert atmosphere; Sealed vial 2.2: 60 °C / Inert atmosphere; Sealed vial View Scheme
参考文献
Molander, Gary A.; Iannazzo, Laura
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9182 - 9187
