6-甲氧基-2-(4-苯甲氧基)苯并噻吩合成路线 （共 35 条）
反应条件
anschliessendes Kochen mit Wasser und Zink-Pulver;
参考文献
v. Wessely et al.
Monatshefte fuer Chemie, 1941 , vol. 73, p. 127,158
反应条件
1: diethyl ether; benzene
2: boron chloride diethyl etherate; tetrachloromethane / 20 °C
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参考文献
v. Wessely et al.
Monatshefte fuer Chemie, 1941 , vol. 73, p. 127,158
反应条件
Reaktion ueber mehrere Stufen;
参考文献
Bush Inc.
Patent: US2410463 , 1943 ;
反应条件
1: diethyl ether; benzene
2: 150 - 160 °C
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参考文献
v. Wessely et al.
Monatshefte fuer Chemie, 1941 , vol. 73, p. 127,158
反应条件
1: NH2OH*HCl, potassium acetate / ethanol
2: 75 percent / aluminum amalgam / ethanol; H2O / 48 h
3: 81 percent / ethanol / 0.5 h / Heating
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参考文献
Omar; Farghaly; Hazzai; Eshba; Sharabi; Daabees
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 9 p. 1075 - 1079
反应条件
1: NH2OH*HCl, potassium acetate / ethanol
2: 75 percent / aluminum amalgam / ethanol; H2O / 48 h
3: 68 percent / ethanol / 0.5 h / Heating
View Scheme
参考文献
Omar; Farghaly; Hazzai; Eshba; Sharabi; Daabees
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 9 p. 1075 - 1079
反应条件
1: NH2OH*HCl, potassium acetate / ethanol
2: 75 percent / aluminum amalgam / ethanol; H2O / 48 h
3: 76 percent / ethanol / 0.5 h / Heating
View Scheme
参考文献
Omar; Farghaly; Hazzai; Eshba; Sharabi; Daabees
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 9 p. 1075 - 1079
反应条件
1: NH2OH*HCl, potassium acetate / ethanol
2: 75 percent / aluminum amalgam / ethanol; H2O / 48 h
3: 90 percent / ethanol / 0.5 h / Heating
View Scheme
参考文献
Omar; Farghaly; Hazzai; Eshba; Sharabi; Daabees
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 9 p. 1075 - 1079
反应条件
1: diethyl ether; benzene
2: KHSO4 / 195 - 200 °C
3: ethanolic KOH / 200 - 210 °C
4: pyridine / 20 °C
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参考文献
Dodds et al.
Proceedings of the Royal Society of London, Series B: Biological Sciences, 1939 , vol. 127, p. 140,153 Anm. 154
Proceedings of the Royal Society of London, 1944 , vol. 132, p. 83,91
反应条件
1: LiSEt / dimethylformamide / 18 h / Heating
2: imidazole / dimethylformamide / 3.5 h / Ambient temperature
3: 70 percent / Zn / benzene / 1 h / Heating
4: 46 percent / SOCl2 / pyridine / 0.25 h / Ambient temperature
5: 82 percent / LiAlH4 / diethyl ether / 0.17 h / Ambient temperature
6: 69 percent / n-Bu4NF / tetrahydrofuran
View Scheme
参考文献
Heys; Hicks; Ruehle
Steroids, 1982 , vol. 39, # 6 p. 681 - 692
