3-苯基丙-2-烯-1-醇合成路线 （共 318 条）
反应条件
1: CH2Cl2 / 2 h / Ambient temperature
2: aq. K2CO3 / methanol / 2.5 h / Ambient temperature
3: Ph3P, Et3N, CBr4 / CH2Cl2 / 1 h / Ambient temperature
4: 3 h
View Scheme
参考文献
Ichikawa, Yoshiyasu; Osada, Masafumi; Ohtani, Ikuko I.; Isobe, Minoru
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 10 p. 1449 - 1455
反应条件
copper diacetate; oxygen; benzene-1,2-diol; palladium diacetate in acetonitrile
T=20°C; 3 h;
参考文献
Kawamura, Yasufumi; Kawano, Yasuhiro; Matsuda, Tomohiro; Ishitobi, Yuta; Hosokawa, Takahiro
Journal of Organic Chemistry, 2009 , vol. 74, # 8 p. 3048 - 3053
反应条件
oxygen; copper diacetate; benzene-1,2-diol; palladium dichloride in acetonitrile
T=20°C; 3 h;
参考文献
Kawamura, Yasufumi; Kawano, Yasuhiro; Matsuda, Tomohiro; Ishitobi, Yuta; Hosokawa, Takahiro
Journal of Organic Chemistry, 2009 , vol. 74, # 8 p. 3048 - 3053
反应条件
diethylzinc in hexane; toluene
T=20°C; 3 h;
参考文献
Mino, Takashi; Hasegawa, Tae; Shirae, Yoshiaki; Sakamoto, Masami; Fujita, Tsutomu
Journal of Organometallic Chemistry, 2007 , vol. 692, # 20 p. 4389 - 4396
反应条件
1: 82 percent / 1.) BuLi / diethyl ether / 1.) -20 deg C, 30 min, 2.) 15 min, -20 deg C, then RT
2: 2.) NH4Cl / 1.) Et2O, -78 deg C, 18 h, 2.) Et2O, -78 deg C
View Scheme
参考文献
Eriksson, Magnus; Hjelmencrantz, Anders; Nilsson, Martin; Olsson, Thomas
Tetrahedron, 1995 , vol. 51, # 46 p. 12631 - 12644
反应条件
silica gel; iron (III) perchlorate in dichloromethane
Heating;
参考文献
Salechi; Khodaei; Ghareghani; Motlagh
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 6 p. 794 - 796
反应条件
Pd(BF4)2(MeCN)4 in methanol; dimethyl sulfoxide
T=50°C; 15 h; Air; regioselective reaction;
参考文献
Selander, Nicklas; Paasch, Jennifer R.; Szabo, Kalman J.
Journal of the American Chemical Society, 2011 , vol. 133, # 3 p. 409 - 411
反应条件
1.1: Et3N; 4-N,N-dimethylaminopyridine / CH2Cl2 / 20 °C
2.1: CuI / tetrahydrofuran / 0.33 h / 0 °C
2.2: 75 percent / tetrahydrofuran / 0 °C
View Scheme
参考文献
Oestreich, Martin; Auer, Gertrud
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 5 p. 637 - 640
反应条件
tetrahydroxydiboron; toluene-4-sulfonic acid; 2,6-(PhSeCH2)2-C6H3-Pd-Cl in methanol; dimethyl sulfoxide
T=50°C; Petasis borono-Mannich reactions; 16 h;
参考文献
Selander, Nicklas; Kipke, Andreas; Sebelius, Sara; Szabo, Kalman J.
Journal of the American Chemical Society, 2007 , vol. 129, # 44 p. 13723 - 13731
反应条件
1: Et3N / CH2Cl2 / Ambient temperature; several hours
View Scheme
参考文献
Nishiyama, Hisao; Kitajima, Toshio; Matsumoto, Makoto; Itoh, Kenji
Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2298 - 2300
