tributylphosphine; copper in tetrahydrofuran other reagent and solvent; Product distribution;

暂无反应条件数据

暂无反应条件数据

暂无反应条件数据

man erhitzt die Loesung des erhaltenen Nitrils;

1: bromine / various solvent(s) 2: 40 percent / 2.) OH(1-) / various solvent(s) / 6 h / Heating View Scheme

1.1: triethylamine / dichloromethane / 4.17 h / -10 - -5 °C / |Large scale 2.1: dimethyl sulfoxide / 4.67 h / 85 °C / |Inert atmosphere; |Large scale 3.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 70 °C / |Inert atmosphere; |Large scale 3.2: 1 h / 20 °C / |Large scale 4.1: sulfuryl dichloride / tert-butyl methyl ether / 1.5 h / 20 - 23 °C / |Large scale 5.1: triethylamine / N,N-dimethyl-formamide / 14 h / 55 °C / |Inert atmosphere; |Large scale 6.1: ammonium acetate / propan-1-ol; ethanol / 1 h / 50 °C / |Inert atmosphere; |Large scale 7.1: sodium cyanoborohydride; alpha-hydroxyethanoic acid / methanol / 20 °C / |Inert atmosphere; |Large scale 8.1: ammonia / methanol / 22 h / 70 °C / 4897.34 Torr / |Sealed tube; |Large scale View Scheme

lead(IV) acetate; calcium carbonate in benzene

1.1: triethylamine / dichloromethane / 4.17 h / -10 - -5 °C / |Large scale 2.1: dimethyl sulfoxide / 4.67 h / 85 °C / |Inert atmosphere; |Large scale 3.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 70 °C / |Inert atmosphere; |Large scale 3.2: 1 h / 20 °C / |Large scale 4.1: sulfuryl dichloride / tert-butyl methyl ether / 1.5 h / 20 - 23 °C / |Large scale 5.1: triethylamine / N,N-dimethyl-formamide / 14 h / 55 °C / |Inert atmosphere; |Large scale 6.1: ammonium acetate / propan-1-ol; ethanol / 1 h / 50 °C / |Inert atmosphere; |Large scale 7.1: sodium cyanoborohydride; alpha-hydroxyethanoic acid / methanol / 20 °C / |Inert atmosphere; |Large scale 8.1: ammonia / methanol / 22 h / 70 °C / 4897.34 Torr / |Sealed tube; |Large scale 9.1: hydrogenchloride / isopropyl alcohol / 4 h / 50 °C / |Large scale 10.1: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; ethyl acetate; 1-methyl-pyrrolidin-2-one / 16 h / 20 - 24 °C 11.1: acetic acid; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; NaMnO4 / tert-butyl methyl ether; water / 12 °C View Scheme

1: 92 percent / pyridine / -15 °C 2: 70 percent / Na / xylene / 24 h / Heating 3: 1) aq. KOH / 1) EtOH, reflux, 2) heating View Scheme