3-(4-甲基苯基)吡啶合成路线 （共 66 条）
反应条件
potassium tert-butylate
T=110°C; 8 h;
参考文献
Bhakuni, Bhagat Singh; Yadav, Abhimanyu; Kumar, Shailesh; Kumar, Sangit
New Journal of Chemistry, 2014 , vol. 38, # 2 p. 827 - 836
反应条件
caesium carbonate; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride; palladium diacetate in 1,4-dioxane
T=120°C; P=37503 Torr; 30 h;
参考文献
Maerten, Eddy; Sauthier, Mathieu; Mortreux, Andre; Castanet, Yves
Tetrahedron, 2007 , vol. 63, # 3 p. 682 - 689
反应条件
1: 3-hydroxy-pyridine With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane
T=100°C; 3 h; Inert atmosphere;
2: p-methylphenylboronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
C52H44CoN4O4; potassium hydroxide; tert-butyl alcohol
T=200°C; 6 h; Inert atmosphereDarkness;
参考文献
Qian, Ying Ying; Wong, Ka Lai; Zhang, Meng Wen; Kwok, Tsz Yiu; To, Ching Tat; Chan, Kin Shing
Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1571 - 1575
反应条件
[NiCl2(PMe3)2] in tetrahydrofuran
T=25°C; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Zhong-Xia
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1641 - 1645
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide in neat (no solvent)
T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium hydroxide in neat (no solvent)
T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
1: 3-fluoropyridine; p-MeC6H4ZnCl With Ni(PCy3)2Cl2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=25 - 100°C; Schlenk techniqueInert atmosphere;
2: p-MeC6H4ZnCl in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; 12 h; Inert atmosphereSchlenk technique;
参考文献
Zhu, Feng; Wang, Zhong-Xia
Journal of Organic Chemistry, 2014 , vol. 79, # 10 p. 4285 - 4292
反应条件
potassium phosphate; Ni(PCy3)2Cl2; PCy3∙HBF4 in o-xylene
T=150°C; Suzuki-Miyaura cross-coupling; 5 - 20 h; Inert atmosphere;
参考文献
Quasdorf, Kyle W.; Antoft-Finch, Aurora; Liu, Peng; Silberstein, Amanda L.; Komaromi, Anna; Blackburn, Tom; Ramgren, Stephen D.; Houk; Snieckus, Victor; Garg, Neil K.
Journal of the American Chemical Society, 2011 , vol. 133, # 16 p. 6352 - 6363
反应条件
1: (4-Methylphenyl)-magnesium bromide With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane
T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere;
2: pyridin-3-yl tosylate in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Ackermann, Lutz; Kapdi, Anant R.; Fenner, Sabine; Kornhaab, Christoph; Schulzke, Carola
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2965 - 2971
