1,4-二氧杂螺[4.5]-2-癸酮合成路线 （共 29 条）
反应条件
toluene-4-sulfonic acid in toluene 9 h; Heating;
参考文献
Perez, Manuel; Perez, Daniel I.; Martinez, Ana; Castro, Ana; Gomez, Generosa; Fall, Yagamare
Chemical Communications, 2009 , # 22 p. 3252 - 3254
反应条件
trimethylsilyl iodide in dichloromethane T=-78°C; 3 h;
参考文献
Pearson, William H.; Cheng, Minn-Chang
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1353 - 1355
反应条件
trimethylsilyl trifluoromethanesulfonate in dichloromethane T=-78°C; 4 h;
参考文献
Pearson, William H.; Cheng, Minn-Chang
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1353 - 1355
反应条件
glyoxylic acid tert-butyl ester in toluene 1 h; Ambient temperature;
参考文献
Ramage, Robert; McCleery, Patrick P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1555 - 1560
反应条件
1: 65 percent / toluene / 1 h / Heating 2: NaOH / H2O; tetrahydrofuran / 18 h / Ambient temperature 3: 73 percent / toluene-p-sulphonic acid hydrate / toluene / 9 h / Heating View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
1: 79 percent / toluene / 20 °C 2: 1,4-diazabicyclo<2.2.2>octane / benzene / 0.07 h / Ambient temperature 3: 65 percent / toluene / 1 h / Heating 4: NaOH / H2O; tetrahydrofuran / 18 h / Ambient temperature 5: 73 percent / toluene-p-sulphonic acid hydrate / toluene / 9 h / Heating View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
1: 1,4-diazabicyclo<2.2.2>octane / benzene / 0.07 h / Ambient temperature 2: 65 percent / toluene / 1 h / Heating 3: NaOH / H2O; tetrahydrofuran / 18 h / Ambient temperature 4: 73 percent / toluene-p-sulphonic acid hydrate / toluene / 9 h / Heating View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
1: NaOH / H2O; tetrahydrofuran / 18 h / Ambient temperature 2: 73 percent / toluene-p-sulphonic acid hydrate / toluene / 9 h / Heating View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
1: NaOH / H2O; tetrahydrofuran / 18 h / Ambient temperature 2: 73 percent / toluene-p-sulphonic acid hydrate / toluene / 9 h / Heating View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
1: NaOH / H2O; tetrahydrofuran / 18 h / Ambient temperature 2: 73 percent / toluene-p-sulphonic acid hydrate / toluene / 9 h / Heating View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
