(2E)-9-羟基-2-癸烯酸合成路线 （共 31 条）
反应条件
1: 98 percent / KOH / ethanol / 2 h / Heating
2: 86 percent / diethyl ether / 0 - 20 °C
3: 80 percent / pyridine / 48 h / 2 - 20 °C
4: SOCl2 / 0.5 h / 65 - 70 °C
5: Br2 / SOCl2 / 5 h / 60 °C
6: 6.79 g / 2 h / Heating
7: CaCO3 / N,N-dimethyl-acetamide / 2 h / Heating
8: 2.47 g / aq. KOH / methanol / 10 h / Heating
View Scheme
参考文献
Kharisov; Botsman; Ishmuratova; Ishmuratov; Tolstikov
Chemistry of Natural Compounds, 2002 , vol. 38, # 2 p. 145 - 148
反应条件
1: 80 percent / pyridine / 48 h / 2 - 20 °C
2: SOCl2 / 0.5 h / 65 - 70 °C
3: Br2 / SOCl2 / 5 h / 60 °C
4: 6.79 g / 2 h / Heating
5: CaCO3 / N,N-dimethyl-acetamide / 2 h / Heating
6: 2.47 g / aq. KOH / methanol / 10 h / Heating
View Scheme
参考文献
Kharisov; Botsman; Ishmuratova; Ishmuratov; Tolstikov
Chemistry of Natural Compounds, 2002 , vol. 38, # 2 p. 145 - 148
反应条件
1: SOCl2 / 0.5 h / 65 - 70 °C
2: Br2 / SOCl2 / 5 h / 60 °C
3: 6.79 g / 2 h / Heating
4: CaCO3 / N,N-dimethyl-acetamide / 2 h / Heating
5: 2.47 g / aq. KOH / methanol / 10 h / Heating
View Scheme
参考文献
Kharisov; Botsman; Ishmuratova; Ishmuratov; Tolstikov
Chemistry of Natural Compounds, 2002 , vol. 38, # 2 p. 145 - 148
反应条件
1: CaCO3 / N,N-dimethyl-acetamide / 2 h / Heating
2: 2.47 g / aq. KOH / methanol / 10 h / Heating
View Scheme
参考文献
Kharisov; Botsman; Ishmuratova; Ishmuratov; Tolstikov
Chemistry of Natural Compounds, 2002 , vol. 38, # 2 p. 145 - 148
反应条件
1: 72 percent / diphenyldisulfide / cyclohexane / 1.83 h / Irradiation
2: 99 percent / 2N KOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Schweitzer, Stefan; Voss, Gundula; Gerlach, Hans
Liebigs Annalen der Chemie, 1994 , # 2 p. 189 - 192
反应条件
1: KHSO4 / Heating
2: (i) O3, AcOH, (ii) Zn, H2O
3: pyridine / Heating
4: (i) NaOH, MeOH, (ii) NaBH4, MeOH
View Scheme
参考文献
Barbier,M.; Huegel,M.-F.
Bulletin de la Societe Chimique de France, 1961 , p. 951 - 954
反应条件
2: KHSO4 / Heating
3: (i) O3, AcOH, (ii) Zn, H2O
4: pyridine / Heating
5: (i) NaOH, MeOH, (ii) NaBH4, MeOH
View Scheme
参考文献
Barbier,M.; Huegel,M.-F.
Bulletin de la Societe Chimique de France, 1961 , p. 951 - 954
反应条件
1: aq. HCl / dioxane / Heating
2: KBH4 / methanol
View Scheme
参考文献
Eiter,K.
Justus Liebigs Annalen der Chemie, 1962 , vol. 658, p. 91 - 99
反应条件
1: Na2CO3 / dioxane / 150 °C
2: KBH4 / methanol
View Scheme
参考文献
Eiter,K.
Justus Liebigs Annalen der Chemie, 1962 , vol. 658, p. 91 - 99
反应条件
1: pyridine / Heating
2: (i) NaOH, MeOH, (ii) NaBH4, MeOH
View Scheme
参考文献
Barbier,M.; Huegel,M.-F.
Bulletin de la Societe Chimique de France, 1961 , p. 951 - 954
