2,4-二氟-1-硝基苯合成路线 （共 113 条）
反应条件
ammonium hydroxide in 1-methyl-pyrrolidin-2-one T=20°C; 24 h;
参考文献
Back, Jong-Beom; Harris, Frank W.
Macromolecules, 2005 , vol. 38, # 2 p. 297 - 306
参考文献
Chiron Coporation
Patent: US2003/28018 A1, 2003 ;
US 20030028018 A1
Title/Abstract Full Text Show Details
Renhowe, Paul A.; Pecchi, Sabina; Machajewski, Timothy D.; Shafer, Cynthia M.; Taylor, Clarke; McCrea JR., William R.; McBride, Christopher; Jazan, Elisa
Patent: US2002/107392 A1, 2002 ;
反应条件
1: phenol With iron(III) chloride; lithium in ammonia T=-40°C; Metallation; 2: 2,4-difluoro-1-nitro-benzene in ammonia T=-33°C; Substitution; 10 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
反应条件
1: p-cresol With iron(III) chloride; lithium in ammonia T=-40°C; Metallation; 2: 2,4-difluoro-1-nitro-benzene in ammonia T=-33°C; Substitution; 10 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
反应条件
1: 3-methyl-phenol With iron(III) chloride; lithium in ammonia T=-40°C; Metallation; 2: 2,4-difluoro-1-nitro-benzene in ammonia T=-33°C; Substitution; 10 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
反应条件
1: 4-Fluorophenyl alcohol With iron(III) chloride; lithium in ammonia T=-40°C; Metallation; 2: 2,4-difluoro-1-nitro-benzene in ammonia T=-33°C; Substitution; 10 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
反应条件
1: 4-methoxy-phenol With iron(III) chloride; lithium in ammonia T=-40°C; Metallation; 2: 2,4-difluoro-1-nitro-benzene in ammonia T=-33°C; Substitution; 6 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
反应条件
1: para-ethyl phenol With iron(III) chloride; lithium in ammonia 2: 2,4-difluoro-1-nitro-benzene With ammonia T=-55 - -33°C; 0.5 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
反应条件
1: 4-(2-propyl)phenol With iron(III) chloride; lithium in ammonia 2: 2,4-difluoro-1-nitro-benzene With ammonia T=-55 - -33°C; 0.833333 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
反应条件
1: 4-tert-butyl-phenol With iron(III) chloride; lithium in ammonia 2: 2,4-difluoro-1-nitro-benzene With ammonia T=-55 - -33°C; 0.833333 h; Title compound not separated from byproducts;
参考文献
Politanskaya, Larisa; Malykhin, Evgenij; Shteingarts, Vitalij
European Journal of Organic Chemistry, 2001 , # 2 p. 405 - 411
