反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 18 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 5 °C
3.1: phosphorus tribromide / diethyl ether / 1 h / 20 °C
4.1: toluene / 18 h / Reflux
View Scheme
参考文献
Matthews, Jay M.; Qin, Ning; Colburn, Raymond W.; Dax, Scott L.; Hawkins, Mike; McNally, James J.; Reany, Laura; Youngman, Mark A.; Baker, Judith; Hutchinson, Tasha; Liu, Yi; Lubin, Mary Lou; Neeper, Michael; Brandt, Michael R.; Stone, Dennis J.; Flores, Christopher M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2922 - 2926