4-氟-2-硝基乙酰苯胺合成路线 （共 23 条）
反应条件
in tetrahydrofuran T=-78 - 40°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; WANG, Tao; ZHANG, Zhongxing; YIN, Zhiwei; KADOW, John, F.; MEANWELL, Nicholas, A.
Patent: WO2012/19003 A1, 2012 ;
Location in patent: Page/Page column 103 ;
反应条件
1.1: hydrogenchloride / water / Reflux
2.1: diethyl ether / 1 h / 100 °C
2.2: 3 h / 50 - 110 °C
2.3: 3 h / 50 - 110 °C
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参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
1: conc. sulfuric acid / 0.25 h / 100 °C
2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min
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参考文献
Ghosh; Ternai; Whitehouse
Journal of medicinal chemistry, 1972 , vol. 15, # 3 p. 255 - 260
