反应条件
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 15 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / hexane; diethyl ether; tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
2.2: 18 h / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
GREEN CROSS CORPORATION; LEE, Jinhwa; KIM, Jeongmin; LEE, Suk Ho; LEE, Junwon; SONG, Kwang-Seop; PARK, Eun-Jung; KIM, Min Ju; SEO, Hee Jeong; LEE, Sung-Han; SON, Eun Jung; KIM, Jong Yup; KANG, Suk Youn; KONG, Younggyu
Patent: WO2011/159067 A2, 2011 ;
WO 2011/159067 A2