1: 1-bromo-3-methyl-butane With magnesium in tetrahydrofuran
T=20 - 35°C; 1 h;
2: p-(trifluoromethyl)-benzonitrile With copper(I) bromide in tetrahydrofuran; toluene
T=25°C; 1 h;
3: With sulfuric acid; water in tetrahydrofuran; toluene
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2007/54739 A1, 2007 ;
Location in patent: Page/Page column 18 ;
WO 2007/054739 A1