2-氯代-4'-氟苯乙酮合成路线 （共 49 条）
反应条件
in methanol T=25°C; Kinetics; Concentration;
参考文献
Tagawa, Kohei; Sasagawa, Keita; Wakisaka, Ken; Monjiyama, Shunsuke; Katayama, Mika; Yamataka, Hiroshi
Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 1 p. 119 - 126
反应条件
1: N,N-dimethyl-formamide / 10 h / 90 °C 2: potassium carbonate; methanol / 2 h / 20 °C View Scheme
参考文献
Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP2465847 A1, 2012 ;
反应条件
bismuth(III) chloride; sodium tetrahydroborate; sodium iodide in acetone Ambient temperature;
参考文献
Ren, Ping-Da; Jin, Qi-Hui; Yao, Zi-Peng
Synthetic Communications, 1997 , vol. 27, # 15 p. 2577 - 2581
反应条件
in methanol T=0°C; Product distribution;
参考文献
Keglevich, Gyoergy; Petnehazy, Imre; Toeke, Laszlo
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 29, p. 341 - 350
反应条件
in ethanol T=0°C; Product distribution;
参考文献
Keglevich, Gyoergy; Petnehazy, Imre; Toeke, Laszlo
Phosphorus and Sulfur and the Related Elements, 1987 , vol. 29, p. 341 - 350
参考文献
Walchshofer; Minjat; Tinland; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 1 p. 59 - 64
反应条件
palladium(II) 2,4-pentanedionate; tributyl-amine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene T=90°C; P=7500.75 Torr; 15 h; Inert atmosphereAutoclaveSchlenk technique;
参考文献
Wahl, Benoit; Bonin, Helene; Mortreux, Andre; Sauthier, Mathieu; Giboulot, Steven; Liron, Frederic; Poli, Giovanni
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 3105 - 3114,10
反应条件
potassium carbonate in acetonitrile T=85°C; 0.833333 h; microwave irradiation;
参考文献
Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483
反应条件
potassium carbonate in acetonitrile T=20°C; 5 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 8 p. 1148 - 1153
反应条件
triethylamine in N,N-dimethyl-formamide T=0 - 20°C; 2 h;
参考文献
Eisai Co., Ltd.
Patent: US2005/227959 A1, 2005 ;
Location in patent: Page/Page column 35 ;
