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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
3-氟苯甲醛肟
合成路线
（共 16 条）
458-02-6
3-氟苯甲醛肟
→
反应条件
455-67-4
3-氟苯丙酮
反应条件
1.1: acetic anhydride / 2 h / 110 °C 2.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C 2.2: 1 h / 40 °C View Scheme
参考文献
Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti
Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667
458-02-6
3-氟苯甲醛肟
→
反应条件
403-54-3
3-氟苯腈
+
456-48-4
3-氟苯甲醛
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in acetonitrile 0.5 h; Photolysis; Title compound not separated from byproducts;
参考文献
De Lijser, H.J. Peter; Hsu, Susan; Marquez, Bernadette V.; Park, Adriana; Sanguantrakun, Nawaporn; Sawyer, Jody R.
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7785 - 7792
458-02-6
3-氟苯甲醛肟
→
反应条件
403-54-3
3-氟苯腈
反应条件
acetic anhydride T=110°C; 2 h;
参考文献
Jasem, Yosef Al; Barkhad, Mohamed; Khazali, Mona Al; Butt, Hifsa Pervez; El-Khwass, Noha Ashraf; Azani, Mariam Al; Hindawi, Bassam Al; Thiemann, Thies
Journal of Chemical Research, 2014 , vol. 38, # 2 p. 80 - 84
458-02-6
3-氟苯甲醛肟
→
反应条件
403-54-3
3-氟苯腈
+
456-48-4
3-氟苯甲醛
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in acetonitrile 0.5 h; Photolysis; Title compound not separated from byproducts;
参考文献
De Lijser, H.J. Peter; Hsu, Susan; Marquez, Bernadette V.; Park, Adriana; Sanguantrakun, Nawaporn; Sawyer, Jody R.
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7785 - 7792
458-02-6
3-氟苯甲醛肟
→
反应条件
86639-52-3
7-乙基-10-羟基喜树碱
反应条件
1.1: acetic anhydride / 2 h / 110 °C 2.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C 2.2: 1 h / 40 °C 3.1: nitric acid / dichloromethane / 12 h / 10 - 20 °C 4.1: sodium hydroxide / 2 h / 0 - 20 °C 5.1: lithium chloride / N,N-dimethyl-formamide / 6 h / |Reflux 6.1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C 7.1: trifluoroacetic acid / toluene / 6 h / 80 °C View Scheme
参考文献
Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti
Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667
458-02-6
3-氟苯甲醛肟
→
反应条件
97682-44-5
伊立替康
反应条件
1.1: acetic anhydride / 2 h / 110 °C 2.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C 2.2: 1 h / 40 °C 3.1: nitric acid / dichloromethane / 12 h / 10 - 20 °C 4.1: sodium hydroxide / 2 h / 0 - 20 °C 5.1: lithium chloride / N,N-dimethyl-formamide / 6 h / |Reflux 6.1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C 7.1: trifluoroacetic acid / toluene / 6 h / 80 °C 8.1: triethylamine; pyridine / 2 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti
Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667
458-02-6
3-氟苯甲醛肟
→
反应条件
885273-52-9
3-(3-氟苯基)-异噁唑-5-甲醛
反应条件
1.1: N-chloro-succinimide; pyridine / tetrahydrofuran / 0.67 h / 60 °C / |Inert atmosphere 1.2: 2 h / 50 °C / |Inert atmosphere 2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / |Molecular sieve View Scheme
参考文献
Oh, Yoo Na; Kwak, Jumyung; Koh, Hun Yeong; Jung, Sun Ho
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 12 p. 4227 - 4230
458-02-6
3-氟苯甲醛肟
→
反应条件
86639-52-3
7-乙基-10-羟基喜树碱
反应条件
1.1: acetic anhydride / 2 h / 110 °C 2.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C 2.2: 1 h / 40 °C 3.1: nitric acid / dichloromethane / 12 h / 10 - 20 °C 4.1: sodium hydroxide / 2 h / 0 - 20 °C 5.1: lithium chloride / N,N-dimethyl-formamide / 6 h / |Reflux 6.1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C 7.1: trifluoroacetic acid / toluene / 6 h / 80 °C View Scheme
参考文献
Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti
Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667
458-02-6
3-氟苯甲醛肟
→
反应条件
100286-90-6
盐酸伊立替康
反应条件
1.1: acetic anhydride / 2 h / 110 °C 2.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C 2.2: 1 h / 40 °C 3.1: nitric acid / dichloromethane / 12 h / 10 - 20 °C 4.1: sodium hydroxide / 2 h / 0 - 20 °C 5.1: lithium chloride / N,N-dimethyl-formamide / 6 h / |Reflux 6.1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C 7.1: trifluoroacetic acid / toluene / 6 h / 80 °C 8.1: triethylamine; pyridine / 2 h / 20 °C / |Inert atmosphere 9.1: hydrogenchloride; water / 3 h / 20 - 70 °C View Scheme
参考文献
Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti
Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667
458-02-6
3-氟苯甲醛肟
→
反应条件
1159251-38-3
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 - 35 °C 2: triethylamine / diethyl ether / 0 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
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