1: With copper(l) iodide; potassium carbonate in dimethyl sulfoxide T=100°C; 12 h; 2: With hydrogenchloride in water pH=~ 2; 3: With ammonia in methanol; water
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/102318 A1, 2009 ;
Location in patent: Page/Page column 91-92 ;
WO 2009/102318 A1
1: 5-bromo-pyrimidine With n-butyllithium in tetrahydrofuran T=-100°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water
