N-(2-氯乙酰基)-beta-丙氨酸合成路线 （共 4 条）
反应条件
in tetrahydrofuran T=0°C; 2.5 h; RefluxInert atmosphere;
参考文献
Ha, Khanh; Monbaliu, Jean-Christophe M.; Williams, Byron C.; Pillai, Girinath G.; Ocampo, Charles E.; Zeller, Matthias; Stevens, Christian V.; Katritzky, Alan R.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 40 p. 8055 - 8058
参考文献
Hanson; Smith
Journal of Biological Chemistry, 1948 , vol. 175, p. 843
反应条件
1: water; NH3
2: aqueous NaOH / 0 °C
3: aqueous methanol.acetic acid; palladium / Hydrogenolyse
View Scheme
参考文献
Hanson; Smith
Journal of Biological Chemistry, 1948 , vol. 175, p. 843
反应条件
1.1: sodium azide / methanol / 72 h / 80 °C / |Inert atmosphere
2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.08 h / 0 °C / |Inert atmosphere
2.2: 24 h / 20 °C / |Inert atmosphere
3.1: tributylphosphine / tetrahydrofuran / |Inert atmosphere; |Microwave irradiation
View Scheme
参考文献
Ha, Khanh; Monbaliu, Jean-Christophe M.; Williams, Byron C.; Pillai, Girinath G.; Ocampo, Charles E.; Zeller, Matthias; Stevens, Christian V.; Katritzky, Alan R.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 40 p. 8055 - 8058
