1: 77 percent / LDA / tetrahydrofuran; hexane / 1 h / -78 - 20 °C 2: 1.) LDA / 1.) THF, hexane, -78 deg C, 5 h, 2.) THF, hexane, -78 deg C to RT, 1.5 h View Scheme

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 0.7 h, 2.) THF, hexane, -78 deg C to RT, 12 h 2: 1.) LDA, 2.) H2O / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 3 min View Scheme

lithium diisopropyl amide in tetrahydrofuran; hexane T=-78 - 20°C; 12 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />3&nbsp;h;&nbsp;<br /> &nbsp;

&nbsp;(i) Na, Et₂O, (ii) /BRN= 1209232/;&nbsp;&nbsp;Multistep reaction;&nbsp;<br /> &nbsp;