1H-吡咯并[2,3-B]吡啶-3-甲醛合成路线 (共 29 条)
反应条件
trichlorophosphate T=100°C; Vilsmeier-Haack reaction; 12 h;
参考文献
Yadav, Rammohan R.; Battini, Narsaiah; Mudududdla, Ramesh; Bharate, Jaideep B.; Muparappu, Nagaraju; Bharate, Sandip B.; Vishwakarma, Ram A.
Tetrahedron Letters, 2012 , vol. 53, # 17 p. 2222 - 2225
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in water T=20 - 120°C; 15 h;
参考文献
Chen, Shaoqing; Sidduri, Achyutharao
Patent: US2006/84674 A1, 2006 ;
Location in patent: Page/Page column 7 ;
US 20060084674 A1
反应条件
1: With acetic acid Duff reaction; 6 h; Heating; 2: With water T=20°C; Further stages.;
参考文献
Bahekar, Rajesh H.; Jain, Mukul R.; Jadav, Pradip A.; Prajapati, Vijay M.; Patel, Dipam N.; Gupta, Arun A.; Sharma, Ajay; Tom, Robby; Bandyopadhya, Debdutta; Modi, Honey; Patel, Pankaj R.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6782 - 6795
反应条件
AlCl3, aluminium chloride in nitromethane; 1,2-dichloro-ethane T=0°C; 1.5 h;
参考文献
Le Borgne, Marc; Na, Young Min; Pagniez, Fabrice; Le Baut, Guillaume; Le Pape, Patrice; Abdala, Hiam
Patent: US2004/67998 A1, 2004 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 3-bromo-1H-pyrrolo[2,3-b]pyridine With n-butyllithium in tetrahydrofuran; hexane T=-70 - -10°C; 5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=20°C; 15 h;
参考文献
Chen, Shaoqing; Sidduri, Achyutharao
Patent: US2006/84674 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
US 20060084674 A1
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; acetic acid 4 h; Reflux;
参考文献
Cheng, Xinlai; Merz, Karl-Heinz; Vatter, Sandra; Christ, Jochen; Woelfl, Stefan; Eisenbrand, Gerhard
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 247 - 255
反应条件
propionic acid in water 3 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/153868 A1, 2008 ;
Location in patent: Page/Page column 24 ;
US 20080153868 A1
反应条件
trichlorophosphate in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Journal of the American Chemical Society, , vol. 77, p. 457,458, 6554, 6555
反应条件
trichlorophosphate T=80°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 17 p. 5981 - 5996