CBZ-GLU(OME)-OH合成路线 （共 22 条）
反应条件
1: tributylamine; chlorocarbonic acid ethyl ester; dioxane / anschliessend Behandeln mit L-Glutamin und wss. NaOH 2: methanol. NH3 3: palladium; aqueous methanol; acetic acid / Hydrogenation 4: H2O View Scheme
参考文献
Shiba; Imai
Nippon Kagaku Zasshi, 1959 , vol. 80, p. 492,494
Chem.Abstr., 1961 , p. 3452
反应条件
1: Et3N / ethyl acetate / Heating 2: aq. HBr / acetic acid 3: DCC / ethyl acetate 4: H2 / Pd-C / methanol; H2O 5: aq. NH3 View Scheme
参考文献
Shimonishi,Y.
Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 200 - 203
反应条件
1: Boc2O; DMAP 2: NaOH / methanol; H2O View Scheme
参考文献
Camble; Purkayastha; Young
Journal of the Chemical Society. Perkin transactions 1, 1968 , vol. 10, p. 1219 - 1224
反应条件
(i) HClO4, (ii) aq. NaOH, acetone; Multistep reaction;
参考文献
Taschner,E. et al.
Justus Liebigs Annalen der Chemie, 1961 , vol. 646, p. 127 - 133
反应条件
sodium dioctyl sulfosuccinate in 2,2,4-trimethylpentane; water 48 h; Product distribution;
参考文献
Ranganathan, D.; Singh, G. P.; Ranganathan, S.
Journal of the American Chemical Society, 1989 , vol. 111, # 3 p. 1144 - 1145
反应条件
1: Et3N / ethyl acetate / Heating 2: aq. HBr / acetic acid 3: DCC / ethyl acetate 4: H2 / Pd-C / methanol; H2O 5: aq. NH3 View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 37, p. 200 - 203
反应条件
1: With Barlos chlorotrityl resin 2: With sodium trimethyl-silanolate in tetrahydrofuran 24 h; 3: With scavenger TIPS; trifluoroacetic acid in tetrahydrofuran; dichloromethane
参考文献
Minta, Ewelina; Boutonnet, Cedric; Boutard, Nicolas; Martinez, Jean; Rolland, Valerie
Tetrahedron Letters, 2005 , vol. 46, # 11 p. 1795 - 1797
反应条件
1: 59.1 percent / EEDQ / diethyl ether / 2 h / Ambient temperature 2: 79.9 percent / HCl (gas) / acetic acid / 2 h / Heating 3: 100 percent / Et3N / methanol / 15 h / Heating 4: 100 percent / aq. Ba(OH)2 / methanol / 15 h View Scheme
参考文献
Jerumanis, Stanislas; Lefebvre, Jean
Bulletin des Societes Chimiques Belges, 1994 , vol. 103, # 3 p. 127 - 130
反应条件
1: DCC / CH2Cl2
2: TsOH / benzene
3: H2 / Pd-C / aq. ethanol
4: aq. Ba(OH)2, CuSO4
View Scheme
参考文献
Moore; Rydon; Smithers
Journal of the Chemical Society. Perkin transactions 1, 1966 , vol. 24, p. 2349 - 2359
反应条件
1: chlorocarbonic acid isobutyl ester; triethylamine; CHCl3 / anschliessend Behandeln mit L-Tyrosin-methylester
2: aqueous NaOH
View Scheme
参考文献
Schellenberg; Ullrich
Chemische Berichte, 1959 , vol. 92, p. 1276,1279
