1: With sodium tetrahydroborate in methanol; water
T=0 - 20°C; 18 h;
2: With hydrogenchloride; water in methanol
pH=2;
3: With sodium hydroxide; water in methanol
pH=10;
参考文献
JE IL PHARMACEUTICAL CO., LTD.; CHOI, Jong-Hee
Patent: WO2009/61131 A2, 2009 ;
Location in patent: Page/Page column 70-71 ;
