4-(哌啶-1-甲基)苯甲醛合成路线 （共 5 条）
反应条件
caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate in water T=95°C; Suzuki-Miyaura cross-coupling;
参考文献
Molander, Gary A.; Sandrock, Deidre L.
Organic Letters, 2007 , vol. 9, # 8 p. 1597 - 1600
反应条件
caesium carbonate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water T=95°C; Suzuki-Miyaura cross-coupling reaction;
参考文献
Molander, Gary A.; Gormisky, Paul E.; Sandrock, Deidre L.
Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2052 - 2057
反应条件
1: With titanium(IV) isopropylate in ethanol T=20°C; 12 h; 2: With sodium tetrahydroborate in ethanol 12 h;
参考文献
Miko, Tibor; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2727 - 2736
反应条件
potassium phosphate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water; tert-butyl alcohol T=110°C; Csp2-Csp3 Suzuki-Miyaura cross-coupling; 18 h; Inert atmosphereSealed tube;
参考文献
Molander, Gary A.; Beaumard, Floriane
Organic Letters, 2011 , vol. 13, # 5 p. 1242 - 1245
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; pentane T=20°C; 2 h;
参考文献
Sheng, Rong; Xu, Yu; Hu, Chunqi; Zhang, Jing; Lin, Xiao; Li, Jingya; Yang, Bo; He, Qiaojun; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 7 - 17
