(2-氧代-2-吡啶-3-基-乙基)-氨基甲酸叔丁酯合成路线 (共 2 条)
反应条件
hydrogenchloride in methanol; isopropyl alcohol T=50°C; 2 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/65217 A1, 2006 ;
Location in patent: Page/Page column 23 ;
WO 2006/065217 A1
反应条件
1: 3-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran
T=20°C; 1 h;
2: N-(tert-butoxycarbonyl)glycine N'-methoxy-N'-methylamide in tetrahydrofuran
T=-15 - 20°C;
参考文献
ASTRAZENECA AB
Patent: WO2005/61510 A1, 2005 ;
Location in patent: Page/Page column 24 ;
WO 2005/061510 A1