6-甲氧基-3H-异苯并呋喃-1-酮合成路线 （共 34 条）
反应条件
1: aqueous permanganate; acetone
2: concentrated hydrochloric acid; glacial acetic acid
View Scheme
参考文献
Chakravarti; Perkin
Journal of the Chemical Society, 1929 , p. 199
参考文献
Ikeda et al.
Kanazawa Daigaku Yakugakubu Kenkyu Nempo, 1956 , vol. 6, p. 48,50
Kanazawa Daigaku Yakugakubu Kenkyu Nempo, 1957 , vol. 7, p. 64
Chem.Abstr., 1957 , p. 4349,1958 9025
参考文献
Fritsch
Justus Liebigs Annalen der Chemie, 1897 , vol. 296, p. 357
参考文献
Chakravarti; Perkin
Journal of the Chemical Society, 1929 , p. 199
反应条件
potassium hydroxide in methanol; water
T=50°C; 0.5 h;
参考文献
Kamaike, Kazuo; Namiki, Takashi; Kawashima, Etsuko
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 4 p. 469 - 487
反应条件
1: aq. KOH / methanol / 0.5 h / 55 °C
2: 1-methylimidazole / dioxane / 1 h / 20 °C
View Scheme
参考文献
Kamaike, Kazuo; Namiki, Takashi; Kawashima, Etsuko
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 4 p. 469 - 487
参考文献
Kamal et al.
Journal of the Chemical Society, 1950 , p. 3375,3378
反应条件
1: N-bromosuccinimide, α,α'-azobisisobutyronitrile / CCl4 / 1 h / Heating
2: benzene / 24 h / 90 - 95 °C
3: 31.2 percent / triethylamine / CH2Cl2 / 2 h
4: iodine
View Scheme
参考文献
Sakamoto; Ikeda; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2698 - 2707
反应条件
1: 88 percent / KMnO4, OH(1-)
2: 86 percent
View Scheme
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
反应条件
1: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in chlorobenzene
T=85 - 110°C;
2: With sodium hydroxide in water
3: With hydrogenchloride in water
T=0°C; 1 h;
参考文献
Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter; Schattel, Verena; Gruetter, Christian; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5868 - 5877
