1,4-环己二酮单乙二醇缩酮合成路线 （共 270 条）
反应条件
1: [i-PrPPh3](+)Br(-) With sodium hydride in dimethyl sulfoxide T=50°C; 2: 1,4-cyclohexanedione monoacetal in dimethyl sulfoxide T=50°C; Wittig reaction; 16 h;
参考文献
Revial, Gilbert; Jabin, Ivan; Pfau, Michel
Tetrahedron Asymmetry, 2000 , vol. 11, # 24 p. 4975 - 4983
反应条件
1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2Λ54Λ5-catenadi(phosphazene) in tetrahydrofuran; hexane Julia-Kocienski olefination; Heating;
参考文献
Alonso, Diego A.; Fuensanta, Monica; Najera, Carmen
European Journal of Organic Chemistry, 2006 , # 20 p. 4747 - 4754
反应条件
1: i-PrPPh3I With n-butyllithium in tetrahydrofuran; hexane T=0 - 20°C; 0.5 h; 2: 1,4-cyclohexanedione monoacetal in tetrahydrofuran; hexane T=20°C; 1 h; 3: With water in tetrahydrofuran; hexane
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: WO2006/115168 A1, 2006 ;
Location in patent: Page/Page column 101-102 ;
反应条件
1.1: methanol-d1 / 2 h / 20 °C 1.2: 18 h / 25 - 30 °C / pH Ca. 6 2.1: sulfuric acid / water / 95 - 100 °C View Scheme
参考文献
Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
反应条件
1: glacial acetic acid; sodium triacetoxyborohydride / CH2Cl2; tetrahydrofuran / 10 - 20 °C 2: 119 g / hydrochloric acid / H2O / 1 h / Heating 3: 87 percent / hydroxylamine hydrochloride; pyridine / ethanol / 3 h / Heating View Scheme
参考文献
Guzzo, Peter R.; Buckle, Ronald N.; Chou, Ming; Dinn, Sean R.; Flaugh, Michael E.; Kiefer Jr., Anton D.; Ryter, Kendal T.; Sampognaro, Anthony J.; Tregay, Steven W.; Xu, Yao-Chang
Journal of Organic Chemistry, 2003 , vol. 68, # 3 p. 770 - 778
反应条件
zinc in tetrahydrofuran Reformatzky reaction; 8 h; Heating;
参考文献
Liang, Pi-Hui; Hsin, Ling-Wei; Pong, Sung-Ling; Hsu, Chia-Huei; Cheng, Chen-Yu
Journal of the Chinese Chemical Society, 2003 , vol. 50, # 3 A p. 449 - 456
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 20 °C / |Reflux 2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C 3.1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 20208 - 20208
反应条件
1.1: magnesium / tetrahydrofuran 1.2: 0 - 20 °C 2.1: toluene-4-sulfonic acid / benzene / 4 h / |Reflux 3.1: iodine / methanol / 2 h / 20 °C / |Inert atmosphere 3.2: 1 h / 0 °C 4.1: potassium carbonate / acetone / 12 h / |Reflux 5.1: 1.33 h / |Microwave irradiation; |Heating; |Sealed tube View Scheme
参考文献
Tetrahedron Letters, , vol. 55, # 5 p. 1049 - 1051
反应条件
1: 72 percent / potassium tert-butoxide / 1,2-dimethoxy-ethane; ethanol / 3 h / 0 - 20 °C 2: 77 percent / lithium aluminum hydride / tetrahydrofuran / Heating 3: 80 percent / 1 h / 20 °C 4: 77 percent / 90 percent formic acid / 16 h / 20 °C View Scheme
参考文献
Masic, Lucija P.; Kikelj, Danijel
Tetrahedron Letters, 2000 , vol. 41, # 29 p. 5589 - 5592
反应条件
n-butyllithium; ammonium chloride in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; water; ethyl acetate
参考文献
Toyama Chemical Co., Ltd.
Patent: US6384065 B1, 2002 ;
