2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺合成路线 （共 18 条）
反应条件
Diethyl amine; sulfur T=20 - 58°C;
参考文献
Kanwar, Seema; Sharma
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371
反应条件
PPA; phosphoric acid T=110 - 120°C; 5 h;
参考文献
Offermann; Eger; Roth
Archiv der Pharmazie, 1981 , vol. 314, # 2 p. 168 - 175
反应条件
sulfur in morpholine; ethanol T=50 - 60°C; 20 h;
参考文献
ATIR HOLDING S.A.
Patent: WO2008/117269 A2, 2008 ;
Location in patent: Page/Page column 47 ;
WO 2008/117269 A2
反应条件
sulfur; diethylamine in ethanol T=45 - 50°C; Gewald reaction;
参考文献
Saravanan, Janardhanan; Mohan, Shamanna; Roy, Jay Jyoti
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 4365 - 4369
反应条件
1: 27 percent / 0.05 h / Heating 2: 90 percent / 2percent NaOH / 1 h / Heating View Scheme
参考文献
Pech; Schleiermachr; Bohm
Pharmazie, 1989 , vol. 44, # 12 p. 860 - 861
反应条件
1: 95 percent / NaOEt / ethanol / 7 h / Heating 2: 87 percent / POCl3 / 2 h / Heating View Scheme
参考文献
Miyashita, Akira; Fujimoto, Katsuhiro; Okada, Tomomi; Higashino, Takeo
Heterocycles, 1996 , vol. 42, # 2 p. 691 - 699
反应条件
triethylamine T=0 - 20°C; 2 h;
参考文献
PROTEOSTASIS THERAPEUTICS, INC.; CHAMBERS, Robert, J.; FOLEY, Megan; TAIT, Bradley
Patent: WO2013/112651 A2, 2013 ;
Location in patent: Page/Page column 64 ;
反应条件
1: 46 percent / conc. aq. HCl / ethanol / 5 h / Heating 2: 77 percent / POCl3/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h View Scheme
参考文献
Abbas, Safinaz E.; Abdel Gawad, Nagwa M.; George, Riham F.; Akar, Yahya A.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 195 - 204
反应条件
triethylamine in ethanol 6 h; Heating;
参考文献
Mohareb, Rafat M.; Sherif, Sherif M.; Gaber, Hatem M.; Ghabrial, Sami S.; Aziz, Susan I.
Heteroatom Chemistry, 2003 , vol. 14, # 5 p. 459 - 467
反应条件
sodium ethanolate in ethanol 7 h; Heating;
参考文献
Miyashita, Akira; Fujimoto, Katsuhiro; Okada, Tomomi; Higashino, Takeo
Heterocycles, 1996 , vol. 42, # 2 p. 691 - 699
