2,2-二甲基-3-羟基丙酸合成路线 （共 51 条）
参考文献
Franke; Kohn
Monatshefte fuer Chemie, 1904 , vol. 25, p. 866
反应条件
thionyl chloride; N,N-dimethyl-formamide Heating;
参考文献
Bellasio,E.; Gallo,G.G.
Farmaco, Edizione Scientifica, 1970 , vol. 25, p. 295 - 304
参考文献
Wessely
Monatshefte fuer Chemie, 1900 , vol. 21, p. 220
参考文献
Blaise; Marcilly
Bulletin de la Societe Chimique de France, 1904 , vol. <3>31, p. 155
Full Text Show Details
Marcilly
Bulletin de la Societe Chimique de France, 1904 , vol. <3>31, p. 129
反应条件
1: hydrogen bromide / water / 19 h / 100 °C 2: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave 3: hydrogenchloride / 20 h / 20 °C 4: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave View Scheme
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
反应条件
1: hydrogen bromide / water / 19 h / 100 °C 2: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave 3: hydrogenchloride / 20 h / 20 °C View Scheme
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
参考文献
Galiano, Silvia; Ceras, Javier; Cirauqui, Nuria; Perez, Silvia; Juanenea, Laura; Rivera, Gildardo; Aldana, Ignacio; Monge, Antonio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 11 p. 3896 - 3911
参考文献
Hayashi, Daisuke; Kato, Nobuo; Kuzuyama, Tomohisa; Sato, Yasuo; Ohkanda, Junko
Chemical Communications, 2013 , vol. 49, # 49 p. 5535 - 5537
参考文献
Merger,F.
Chemische Berichte, 1968 , vol. 101, p. 2413 - 2418
反应条件
hydrogenchloride in methanol
参考文献
Pharmacia and Upjohn Company
Patent: US5877317 A1, 1999 ;
