2,4,5－三苯基咪唑合成路线 （共 149 条）
反应条件
1: trifluoromethylsulfonic anhydride; N-[(phenyl)(pyrrolidin-1-yl)methylene]benzamide in dichloromethane T=-50°C; 1.5 h; 2: ethyl DL-phenylglycinate hydrogen p-toluenesulfonate With triethylamine in dichloromethane T=20°C; 16 h; Further stages.;
参考文献
Habersaat, Nils; Froehlich, Roland; Wuerthwein, Ernst-Ulrich
European Journal of Organic Chemistry, 2004 , # 12 p. 2567 - 2581
参考文献
SmithKline Beecham Corporation; The Johns Hopkins University
Patent: US5648373 A1, 1997 ;
反应条件
potassium tert-butylate; oxygen in tetrahydrofuran; dimethyl sulfoxide T=20°C; 16 h;
参考文献
Recnik, Lisa-Maria; Abd El Hameid, Mohammed; Haider, Maximilian; Schnuerch, Michael; Mihovilovic, Marko D.
Synthesis (Germany), 2013 , vol. 45, # 10 art. no. SS-2012-Z0934-OP, p. 1387 - 1405
反应条件
potassium tert-butylate; oxygen in dimethyl sulfoxide 2 h; Heating;
参考文献
Lozinskaya; Tsybezova; Proskurnina; Zefirov
Russian Chemical Bulletin, 2003 , vol. 52, # 3 p. 674 - 678
反应条件
zinc in acetic acid 2 h; Heating;
参考文献
Nagy, Jozsef; Horvath, Aniko; Szoelloesy, Aron; Nyitrai, Jozsef
European Journal of Organic Chemistry, 1999 , # 3 p. 685 - 689
反应条件
triphenylphosphine; palladium diacetate T=160°C; 8 h;
参考文献
Ingebrigtsen, Truls; Helland, Irene; Lejon, Tore
Heterocycles, 2005 , vol. 65, # 11 p. 2593 - 2603
反应条件
sodium hydride in tetrahydrofuran 7 h; Heating;
参考文献
Ogonor
Tetrahedron, 1981 , vol. 37, # 16 p. 2909 - 2910
反应条件
magnesium in diethylene glycol dimethyl ether Heatingovernight;
参考文献
Burns, Timothy P.; Rieke, Reuben D.
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3674 - 3680
反应条件
LiCrH4*2LiCl*2THF in tetrahydrofuran T=25°C; 12 h;
参考文献
Eisch, John J.; Shi, Xian; Alila, Joseph R.; Thiele, Sven
Chemische Berichte, 1997 , vol. 130, # 9 p. 1175 - 1187
反应条件
1: ammonium acetate; 2,2,2-trimethylacetic acid / dimethyl sulfoxide; water / 12 h / 140 °C 2: ammonium acetate; 2,2,2-trimethylacetic acid / dimethyl sulfoxide; water / 24 h / 140 °C View Scheme
参考文献
Chen, Chung-Yu; Hu, Wan-Ping; Yan, Pi-Cheng; Senadi, Gopal Chandru; Wang, Jeh-Jeng
Organic Letters, 2013 , vol. 15, # 24 p. 6116 - 6119
