2,2’-二甲氧基联苯合成路线 （共 133 条）
反应条件
1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride; potassium carbonate in water; acetonitrile T=60°C; Suzuki-Miyaura reaction; Inert atmosphereSealed vessel;
参考文献
Moseley, Jonathan D.; Murray, Paul M.; Turp, Edward R.; Tyler, Simon N.G.; Burn, Ross T.
Tetrahedron, 2012 , vol. 68, # 30 p. 6010 - 6017
反应条件
tert.-butyl lithium; triethylamine; iron(II) chloride in tetrahydrofuran T=-78 - 25°C; 4 h; Inert atmosphere;
参考文献
Toummini, Dounia; Ouazzani, Fouad; Taillefer, Marc
Organic Letters, 2013 , vol. 15, # 18 p. 4690 - 4693
反应条件
palladium diacetate; copper dichloride in tetrahydrofuran T=23°C; 0.116667 h;
参考文献
Parrish, Jay P.; Flanders, Vincent L.; Floyd, Ryan J.; Jung, Kyung Woon
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7729 - 7731
反应条件
1: 2-methoxybromobenzene With tert.-butyl lithium in tetrahydrofuran; pentane T=0°C; 1 h; 2: With indium(III) chloride in tetrahydrofuran; pentane T=-78 - 20°C; 3: 6-acetoxy-1-cyclohexene-1-carbonitrile With triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran; pentane Heating;
参考文献
Baker, Lucas; Minehan, Thomas
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3957 - 3960
反应条件
trifluoroacetic acid; cobalt(II) dibromide; zinc dibromide in acetonitrile the mixt. in CH3CN was stirred at room temp., then arylbromide was added, stirred at room temp.; GC analysis;
参考文献
Fillon, Hyacinthe; Gosmini, Corinne; Perichon, Jacques
Journal of the American Chemical Society, 2003 , vol. 125, # 13 p. 3867 - 3870
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; cobalt(II) dibromide in tetrahydrofuran; hexane T=0 - 20°C; 0.5 h; 2: With iodine in tetrahydrofuran; hexane T=20°C; 3: With water; sodium thiosulfate in tetrahydrofuran; hexane
参考文献
Dayaker, Gandrath; Chevallier, Floris; Gros, Philippe C.; Mongin, Florence
Tetrahedron, 2010 , vol. 66, # 46 p. 8904 - 8910
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=25°C; 48 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
反应条件
1: With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=0°C; Substitution; Dimerization; 0.5 h; 2: With silver tetrafluoroborate in tetrahydrofuran; diethyl ether; hexane T=20°C; Oxidation; Alkylation; 2 h; Further stages.;
参考文献
Hirao, Toshikazu; Takada, Takashi; Ogawa, Akiya
Journal of Organic Chemistry, 2000 , vol. 65, # 5 p. 1511 - 1515
反应条件
1,2-dichloro-ethane; manganese (II) chloride in tetrahydrofuran T=25°C; 12 h; Inert atmosphere;
参考文献
Zhou, Zhiming; Xue, Weizhe
Journal of Organometallic Chemistry, 2009 , vol. 694, # 5 p. 599 - 603
反应条件
1: With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=0°C; Substitution; Dimerization; 0.5 h; 2: With [VO(OEt)Cl2] in tetrahydrofuran; diethyl ether; hexane T=20°C; Oxidation; Alkylation; 3 h; Further stages.;
参考文献
Hirao, Toshikazu; Takada, Takashi; Ogawa, Akiya
Journal of Organic Chemistry, 2000 , vol. 65, # 5 p. 1511 - 1515
