N-叔丁基-4-氟苯甲酰胺合成路线 （共 8 条）
反应条件
water; triphenylphosphine; cesium fluoride; palladium dichloride in dimethyl sulfoxide
T=90°C;
参考文献
Jiang, Huanfeng; Liu, Bifu; Li, Yibiao; Wang, Azhong; Huang, Huawen
Organic Letters, 2011 , vol. 13, # 5 p. 1028 - 1031
反应条件
water; triphenylphosphine; cesium fluoride; palladium dichloride in dimethyl sulfoxide
T=110°C; 15 h;
参考文献
Jiang, Huanfeng; Liu, Bifu; Li, Yibiao; Wang, Azhong; Huang, Huawen
Organic Letters, 2011 , vol. 13, # 5 p. 1028 - 1031
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US6384033 B1, 2002 ;
反应条件
sulfuric acid in acetic acid
T=45°C; Ritter reaction; 0.1 h; In flow;
参考文献
Audiger, Logan; Watts, Kevin; Elmore, Simon C.; Robinson, Richard I.; Wirth, Thomas
ChemSusChem, 2012 , vol. 5, # 2 p. 257 - 260
反应条件
potassium fluoride; 18-crown-6 ether; water in tetrahydrofuran
T=30°C; 16 h; Inert atmosphere; Overall yield = 61 percent; Overall yield = 0.060 g; regioselective reaction;
参考文献
Kaicharla, Trinadh; Thangaraj, Manikandan; Biju, Akkattu T.
Organic Letters, 2014 , vol. 16, # 6 p. 1728 - 1731
反应条件
1: 1-tert-butyl-1,2-bis(p-fluorobenzoyl)hydrazine With sodium hydride in N,N-dimethyl-formamide
T=20°C; 2 h;
2: ethyl bromoacetate in N,N-dimethyl-formamide
T=35 - 40°C; 10 h;
参考文献
Cao; Qian; Song
Canadian Journal of Chemistry, 2001 , vol. 79, # 3 p. 272 - 278
反应条件
1,4-diaza-bicyclo[2.2.2]octane in chloroform-d1
参考文献
Spratt, M. P.; Dorn, H. C.
Analytical Chemistry, 1984 , vol. 56, # 12 p. 2038 - 2043
反应条件
air
Ambient temperature;
参考文献
Auret, Barbara J.; Boyd, Derek R.; Coulter, Peter B.
Journal of the Chemical Society, Chemical Communications, 1984 , # 7 p. 463 - 464
