反应条件
1: 1-methylguanidine hydrochloride With sodium methylate in butan-1-ol T=0°C; 0.5 h; 2: (E)-3-dimethylamino-1-(5-chloro-1-isopropyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-propenone in butan-1-ol 18 h; Reflux;
参考文献
MERCK SHARP andamp; DOHME CORP.; BANYU PHARMACEUTICAL CO., LTD.; GOTO, Yasuhiro; SAGARA, Takeshi; FAN, Weiming; HAXELL, Thomas, F. N.; JENKS, Matthew, G.; MALASKA, Michael, J.; MOORE, Joseph, A., III; OUVRY, Gilles; PANDI, Bharathi; PEEL, Michael, R.; STEWARD, Kimberly, M.
Patent: WO2010/42337 A1, 2010 ;
Location in patent: Page/Page column 42; 44; 45 ;
WO 2010/042337 A1